EURECA C.C. EURECA-CC2. Perugia, Italy. 2 nd CONSENSUS CONFERENCE Multidisciplinary rectal cancer treatments: looking for a European Consensus

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1 2 EURECA C.C. EURECA-CC2 2 nd CONSENSUS CONFERENCE Multidisciplinary rectal cancer treatments: looking for a European Consensus Perugia, Italy December, 2008 Centro Congressi della Camera di Commercio Endorsed by European Society for Medical Oncology European Society of Surgical Oncology European Society for Therapeutic Radiology and Oncology

Honorary Presidents Paolo Latini, Numa Cellini Coordinators Cynthia Aristei, Vincenzo Valentini Executive Scientific Committee R. Beets-Tan J.M. Borras P. Boyle B. Glimelius K. Haustermans R. Heald P.

2 Honorary Presidents Paolo Latini, Numa Cellini Coordinators Cynthia Aristei, Vincenzo Valentini Executive Scientific Committee R. Beets-Tan J.M. Borras P. Boyle B. Glimelius K. Haustermans R. Heald P. Maingon B. Minsky Scientific Committee E. Aranda L. Blomqvist J.F. Bosset G. Brown K. Bujko N. Ectors J.P. Gerard R. Glynne-Jones W. Hohenberger T. Holm Secretariat Board C. Coco M.A. Gambacorta D. Genovesi J. Overgaard P. Quirke H.J. Schmoll D. Sebag-Montefiore I. Taylor E. Van Cutsem C. Van de Velde S. Laurberg J.W. Leer C. Marijnen I. Nagtegaal L. Pahlman C. Rodel H. Rutten W. Scheithauer C. Willet M. Lupattelli G. Mantello F. Valvo Thursday 11 December ,00-15,10 Opening Session 15,10 15,30 Epidemiology landscape P. Boyle 15,30 18,30 Session 1: Diagnostic Moderators: R. Beets-Tan, P. Quirke 15,30 Evidence for the role of imaging in identifying early stage tumors and small tumors after chemoradiation R. Beets-Tan 16,00 Evidence for the role of imaging in predicting the poor responders in advanced disease G. Brown 16,30 Evidence for the role of imaging in the follow up after treatment L. Blomqvist 17,00 Evidence to define the response to treatment by pathology P. Quirke 17,30 Debate and Consensus voting Hotel Brufani Palace 18,45 Opening Ceremony Chairmen: P. Latini, N. Cellini J. Bourhis (ESTRO) L. Pahlman (ESSO) H.J. Schmoll (ESMO) P. Muto (AIRO) F. Bistoni (Rector, University of Perugia) P. Magistrelli (Dean of the School of Medicine, UCSC, Rome) A. Puxeddu (Dean of the School of Medicine, University of Perugia) Local Authorities Local Organizing Committee A. Cavaliere F. Checcaglini L. Crinò A. Donini E. Gentile P. Giovenali L. Lupattelli E. Maranzano A. Morelli G. Natalini G. Noya R. Palumbo A. Sidoni M. Tonato 19,30 Welcome Cocktail Sala dei Notari - Town Hall 21,00 Concert

Friday 12 December 2008 8,00-9,00 Satellite Meeting: New trends in Technology 9,00-11,00 Session 2: Early stage Moderators: H. Rutten, P. Maingon 9,00 Natural history of early stage N.

3 Friday 12 December ,00-9,00 Satellite Meeting: New trends in Technology 9,00-11,00 Session 2: Early stage Moderators: H. Rutten, P. Maingon 9,00 Natural history of early stage N. Ectors 9,15 Evidence for mucosectomy in ct1 S. Laurberg 9,30 Evidence for local excision in ct2 W. Hohenberger 9,45 Evidence for local excision ± pre- or postradiotherapy K. Haustermans 10,00 Evidence for radiotherapy alone J.P. Gerard 10,15 Debate and Consensus voting 11,00 11,30 Break 11,30-13,30 Session 3: Intermediate stage: Radiotherapy Moderators: J. Bourhis, B. Minsky 11,30 Natural history of intermediate stage P. Quirke 11,45 Evidence for pre-operative treatment with radiotherapy alone J.W. Leer 12,00 Evidence for pre-operative treatment with radio-chemotherapy C. Rodel 12,15 Evidence for post-operative radio(chemo)therapy C. Willet 12,30 Debate and Consensus voting 15,15 Evidence for organ preservation S. Laurberg 15,30 Debate and Consensus voting 16,30 17,00 Break 17,00 19,00 Session 5: Intermediate stage: chemotherapy Moderators: E. Van Cutsem, B. Glimelius 17,00 Evidence for adjuvant chemotherapy after preoperative radiotherapy B. Glimelius 17,15 Evidence for adjuvant chemotherapy after preoperative radio-chemotherapy E. Van Cutsem 17,30 Evidence for adjuvant chemotherapy with 2 drugs (5FU + Oxaliplatin or Irinotecan) H.J. Schmoll 17,45 Evidence for duration of adjuvant chemotherapy R. Glynne-Jones 18,00 Debate and Consensus voting 13,30 14,30 Lunch 14,30 16,30 Session 4: Intermediate stage: surgery Moderators: L. Pahlman, C. Coco 14,30 Evidence for TME surgery T. Holm 14,45 Evidence for optimized APR surgery L. Pahlman 15,00 Evidence for sphincter saving surgery H. Rutten

Saturday 13 December 2008 8,00 9,00 Satellite Meeting: New drugs in the combined treatment setting 9,00-11,00 Session 6: Advanced stage Moderators: H.J. Schmoll, P.

4 Saturday 13 December ,00 9,00 Satellite Meeting: New drugs in the combined treatment setting 9,00-11,00 Session 6: Advanced stage Moderators: H.J. Schmoll, P. Muto 9,00 Natural history of advanced disease N. Ectors 9,15 Evidence for pre-operative radio(chemo)therapy in T4M0 patients B. Minsky 9,30 Evidence for combined treatment in a single metastases M1 patients W. Scheithauer 9,45 Evidence for a surgical approach in M1 patients L. Pahlamn 10,00 Debate and Consensus voting 11,30-13,30 Session 7: Follow-up and Quality of life Moderators: T. Holm, K. Haustermans 11,30 Evidence for an intensive follow-up D. Sebag-Montefiore 11,45 Evidence for an improvement in QoL C. Marijnen 12,00 Evidence for monitoring sphincter function H. Rutten 12,15 Evidence for radio(chemo)therapy related toxicity K. Bujko 12,30 Debate and Consensus voting 13,30 14,00 Concluding remarks 14,00 14,15 CME (ECM - Educazione Continua in Medicina) 11,00 11,30 Break

5 General Information Congress Venue The Congress will be held at the Conference Center of the Camera di Commercio of Perugia, Via Pellas, 83 - Perugia. Registration In order to participate in the congress, registration is free but obligatory. To register for the congress, fill in the attached enrolment form and send it by fax to the Organizing Secretariat at 075/ The enrolment form is also available online at Note: Congress registrations will be accepted until December 5th After this date, registration can only be accepted at the conference venue and only if places are still available. Attendance certificate To obtain the certificate, participants must present their badges to the Secretariat at the end of the Congress. Hotel Bookings Hotel rates are as follows: Hotel Double Room Double Room: Single Occupancy e 145,00 e 125,00 e 90,00 e 70,00 The rates are per room per day and include breakfast. To make your hotel reservation, send the attached form to the Organizing Secretariat with a copy of the payment of 145,00 (for a 4 star hotel) of which 125,00 as guarantee deposit and 20,00 as agency fee or 90,00 (for 3 star hotel) of which 70,00 as guarantee deposit and 20,00 as agency fee. The final amount due for accommodation, after deduction of the deposit, should be paid directly to the hotel. The Organizing Agency will assign rooms on a first come/ first served basis. The Organizing Agency will send vouchers for the confirmed reservation, notifying participants of the name and address of the assigned hotel. In order to ensure comfortable accommodation we advise participants to send in the hotel reservation form as soon as possible. Cancellations and Refunds For hotel reservation cancellations received by the Organizing Secretariat no later than November 30th, 2008, the amount already paid as deposit shall be reimbursed after deduction of double the amount of the agency fee. After this date, no refunds shall be possible. CME (ECM Educazione Continua in Medicina) The Italian Health Ministry has received the application for recognition of the event for CME (Continuing Medical Education) purposes for 100 participants. Main topic: Radiotherapy Secondary topics: Oncology, General Surgery The CME certificate shall be issued only to those participants who have attended the entire congress as verified by specific checks, and who have given at least 70% correct answers in the questionnaire. It is obligatory to provide all of the information requested in the application form in order to obtain credits. The certificate shall be sent by mail to the address given in the application form in compliance with the foregoing specifications. Payment for hotel reservation may be made by bank transfer into the following account: C.S.C. s.r.l. di Paola Gagliardini Banca Popolare di Spoleto San Sisto Perugia branch, Via Tagliapietre, 3 Bank data: IBAN IT 86 O

Organizing Agency C.S.C. S.r.l. Via L. S. Gualtieri, 11-06123 Perugia Tel. 075/5730617 - Fax 075/5730619 e-mail: info@csccongressi.it www.csccongressi.it Until 10th december 2008 The Organizing Agency C.

6 Organizing Agency C.S.C. S.r.l. Via L. S. Gualtieri, Perugia Tel. 075/ Fax 075/ info@csccongressi.it Until 10th december 2008 The Organizing Agency C.S.C. S.r.l. is open Monday to Friday from 9:00 am to 1:00 pm, and from Monday to Thursday from 3:00 to 6:00 pm. Tel: fax From 11th December 2008 The Conference Secretariat will open at the conference venue at 2:00 pm on December 11th and will follow the timetable of the conference. Participants who are already registered may collect their conference bag and badge at the Already registered Secretariat. Participants who have not registered yet must go to the New registrations Secretariat. Participants not wearing their badges will not be allowed to enter the congress room.

Do you want to contribute to the Consensus Process? Go to www.eureca-cc.org and register yourself. Then you can login and will have access to the ongoing version of the Consensus Document.

The Consensus Process timetable according to the Delphy method is: First run 22nd September 2008-13th October 2008.

7 Do you want to contribute to the Consensus Process? Go to and register yourself. Then you can login and will have access to the ongoing version of the Consensus Document. You can forward us your comments on each part of the different versions of the Consensus Document sending an to and it will be addressed to the Scientific Board. The Consensus Process timetable according to the Delphy method is: First run 22nd September th October All Scientific Members will vote singly Second run 3rd November th November In this second run all members of the Scientific Committee will compare their own proposal with the outcome of the whole Committee after the first run. Perugia Meeting December 2008 Final third run 15th January th February Please, give your contribution Grafica: VIGNATI Stampa: TIPOGRAFIA METASTASIO - ASSISI

8 APPLICATION FORM EURECA-CC2-2nd CONSENSUS CONFERENCE Multidisciplinary rectal cancer treatments: looking for a European Consensus Perugia, December 2008 Fill in capital letters and send to Centro Servizi Congressuali C.S.C. S.r.l. Via L.S. Gualtieri, Perugia - Fax by December 5th Personal Data SURNAME* TITLE * NAME* PROFESSION* DISCIPLINE* ADDRESS * POST CODE.* CITY* COUNTRY.* TEL*. FAX * (only for italians for CME) CF* Luogo di nascita* Prov.* Data di nascita* * Obligatory Data for invoicing (Hotel Booking only) NAME ADDRESS POST CODE CITY COUNTRY VAT NO. (IVA) TAX FILE NO. Hotel Booking I wish to book N. Double Room: Single Occupancy N. Double Room Date of arrival 2008 Date of departure 2008 N. 4 star Room at e 145,00** e N. 3 star Room at e 90,00** e TOTAL HOTEL BOOKING ** The cost per room is 145,00 (for a 4 star hotel) of which 125,00 as deposit and 20,00 as agency fee or 90,00 (for 3 star hotel) of which 70,00 as deposit and 20,00 as agency fee. Method of Payment Bank transfer into the following account: C.S.C. S.r.l. Banca Popolare di Spoleto Agenzia di San Sisto Perugia - Via Tagliapietre, 3 - IBAN IT 86 O N.B. In the bank transfer specify: NAME OF CONGRESS and NAME OF PARTICIPANT Credit Card VISA American Express n. Expiry date e (1) I hereby authorise the C.S.C. to charge to my credit card e, Write the amount from (1) Box Date Signature C.S.C. S.r.l. will address the invoice to firm or company only in the presence of their written claim which should be attached to the application form, (indicating also all fiscal data), along with copy of paid bank transfer. Date Signature PRIVACY LAW: permission is granted to manage, communicate, including by computer, all the data in this form only for the purposes of the Conference and, where applicable, for the CME programme (under the art.13 and 23 of the Decree Law 196/2003). Date Signature Grafica: VIGNATI Stampa: TIPOGRAFIA METASTASIO - ASSISI

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