HESI Emerging Issues Meeting
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1 HESI Emerging Issues Meeting B. Bhaskar Gollapudi, PhD The Dow Chemical Company Chair, Emerging Issues Steering Committee (EISC) HESI Annual Meeting 8 June 2011
2 Meeting Goals Acknowledge incoming and outgoing Members-at-Large and Scientific Advisors of the HESI Emerging Issues Steering Committee (EISC) Outline the Emerging Issues Process Give report on existing HESI Emerging Issues Subcommittee Explore new topic areas for consideration by HESI constituency 2
3 2011 EISC PARTICIPATION 3
4 EISC Leadership (to be elected by HESI Assembly of members, 9 June 2011) CHAIR: Dr. Karen L. Blackburn The Procter & Gamble Company (term expires 2014) VICE CHAIR: Dr. Stephen J. Newsholme GlaxoSmithKline (term expires 2016) PAST CHAIR: Dr. B. Bhaskar Gollapudi The Dow Chemical Company (term expires 2012) 4
5 2011 EISC Members-at-Large (to be elected by HESI Assembly of members, 9 June 2011) Dr. Cynthia A. Afshari newly elected Amgen Inc. (term expires 2014) Dr. Robert A. Barter newly elected ExxonMobil Biomedical Sciences (term expires 2012) Dr. Werner H. Bomann Bayer CropScience (term expires 2012) Dr. Patrick D. Guiney newly elected SC Johnson & Son, Inc. (term expires 2014) Dr. George Pugh, Jr. The Coca-Cola Company (term expires 2013) Dr. Mark A. Tirmenstein Bristol-Myers Squibb Co. (term expires 2013) 5
6 2011 EISC Scientific Advisors (to be elected by HESI Assembly of members, 9 June 2011) Dr. Darlene Dixon re-elected NIEHS (term expires 2014) Dr. Jesse L. Goodman newly elected US FDA (term expires 2014) Dr. George Gray newly elected George Washington University (term expires 2014) Dr. Toshihisa Ishikawa RIKEN Yokohama (term expires 2012) Prof. Ian Kimber University of Manchester (term expires 2013) Dr. James E. Klaunig Indiana University (term expires 2013) Dr. Derek C.G. Muir Environment Canada (term expires 2013) Dr. Gary M. Williams NY Medical College (term expires 2012) Dr. Hal Zenick US EPA (term expires 2012) 6
7 Outgoing EISC Participants (terms ending June 2011) Dr. Serrine S. Lau (Scientific Advisor) University of Arizona Dr. Leonard V. Sacks (Scientific Advisor) US FDA Dr. A. Robert Schnatter (Member-at-Large) ExxonMobil Biomedical Sciences, Inc. Dr. James L. Stevens (Member-at-Large) Eli Lilly and Company 7
8 EMERGING ISSUES PROCESS 8
9 Emerging Issues Process: Issue Identification Annual Survey: Distributed to HESI stakeholders (membership and a broad cross-section of the international scientific community). In proposing new topics, respondents are asked to consider topics in the context of linkages with issues found on the HESI Scientific Map. Results from the survey are examined by the EISC. Using established criteria, the EISC determines which proposals are presented at the HESI Annual Meeting. After the Annual Meeting, HESI stakeholders vote on the highest priority issue for HESI action that year (see form in today s meeting packet). 9
10 Criteria for Issue Identification and Prioritization 1. The issue should be critical for the general scientific community, as well as for current and potential member companies, and should have current public health significance. 2. The issue should have reasonable potential for resolution. 3. The issue should be an area for which HESI has or can identify expertise to contribute. 4. HESI s efforts to address the issue should not be duplicative of other groups. 10
11 Subcommittee Formation and Operation Based on voting results (post-annual Meeting), the EISC selects one emerging issue for HESI action. A Subcommittee is formed. EI projects are resource intensive. Limitations in budget and/or staffing resources may affect adoption or timeline. Funding: Year One: $50,000 in funding from HESI; no fees for participation. Year Two: HESI matches funding raised by committee up to $50,000. Beyond Year Two: If desired, participants petition HESI Board for Project or Technical Committee status; project is then funded entirely by participant dollars. 11
12 EXISTING EMERGING ISSUES SUBCOMMITTEE 12
13 Subcommittee Report Evaluating causality in epidemiologic studies Dr. A. Robert Schnatter (ExxonMobil Biomedical Sciences, Inc.) Subcommittee Steering Team Member 13
14 NEW TOPIC PRESENTATIONS ONE TOPIC WILL BE SELECTED FOR HESI ACTION IN
15 New Topic Presentations Modeling the environmental impact from water withdrawal and disposal across the life cycle of products Dr. Jennifer Orme-Zavaleta (US EPA) Mr. Gert van Hoof (Procter & Gamble) Frameworks for alternative chemical assessment and selection of safer, sustainable alternatives Dr. P. Robert Peoples (ACS Green Chemistry ) Dr. Robert Barter (ExxonMobil Biomedical Sciences0 Dr. Pamela Spencer (Dow Chemical Company) 15
16 New Topic Presentations, cont d. Alveolar macrophage changes in response to inhaled drugs: factors distinguishing adaptive from adverse effects Dr. Jan Klapwijk (GlaxoSmithKline) Dr. Darlene Dixon (NIEHS) Human ips/es cell technology and its application to toxicology testing, especially focusing on in vitro cardiac function toxicity Prof. Kenji Yasuda (Tokyo Medical and Dental University) Dr. Atsushi Sanbuissho (Daiichi Sankyo Co., Ltd.) 16
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