Your Voice in Public Policy to Improve Patient Lives 2017 ANNUAL REPORT

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Takeda Political Action Committee Your Voice in Public Policy to Improve Patient Lives 2017 ANNUAL REPORT

TakPAC s PURPOSE TakPAC offers eligible Takeda employees a way to join together to support the election of candidates, regardless of their political affiliation, who share our vision to drive innovation and ensure patient access. TABLE OF CONTENTS Message from the Chair...3 By the Numbers...4 TakPAC Invests in Innovation...6 TakPAC Financial Statement...7 Who Makes the Decisions?...8 2017 Contributions to Candidates & Committees...9 Public Policies Important to Takeda...12

MESSAGE FROM THE CHAIR Takeda strives on many levels to inform the U.S. public policymaking process about issues important to our work for patients. TakPAC is Takeda s political action committee a fund used to help elect state and federal lawmakers who share our public policy positions related to pharmaceutical innovation, the needs of patients we serve, and matters important to our industry. This program is driven by the voluntary contributions of eligible Takeda employees and is the only legal way Takeda can provide direct support to federal and many state candidates. TakPAC plays a crucial role in helping the Takeda Government and External Affairs (GEA) team to educate elected officials on issues affecting our products and therapeutic areas. It is through TakPAC s direct, bipartisan support of candidates that we can build and strengthen our relationships with lawmakers and impress upon them the important work the pharmaceutical industry accomplishes for patients worldwide. The TakPAC Officers and Board of Advisors want you and all eligible Takeda employees to be fully informed about TakPAC s mission to drive innovation and ensure patient access to our medicines. This annual report provides a full, transparent accounting of TakPAC s financial performance. Our objective is to always be a good steward of employee donations, making sure you know who decides which candidates to support, why specific candidates received our support, and how much we contributed. I encourage you to learn more about TakPAC at www.takedapac.com. Rick Ascroft 2017 TakPAC Chairman Senior Vice President, Managed Markets and Government Affairs Takeda Pharmaceuticals U.S.A., Inc. 3

2017 TakPAC BY THE NUMBERS 3800 TAKEDA U.S. EMPLOYEES ELIGIBLE TO PARTICIPATE IN TakPAC 225% INCREASE OVER 2016 8NEW TakPAC BOARD OF ADVISORS MEMBERS REPRESENTING ALL BUSINESS UNITS & LOCATIONS TakPAC DONORS 98% CONTRIBUTING THROUGH RECURRING PAYROLL DEDUCTION $95,648.19 TOTAL VOLUNTARY CONTRIBUTIONS FROM ELIGIBLE TAKEDA EMPLOYEES 33% INCREASE OVER 2016 $84,000 55 CONTRIBUTED TO FEDERAL CANDIDATES & COMMITTEES 4 4

2017 TakPAC BY THE NUMBERS 2017 PAC RECEIPTS 5

TakPAC Supports Innovation Takeda Political Action Committee Supports candidates who champion policies important to Takeda Healthcare Reform Medicare Reform Drug Pricing/ Transparency Patient Issues Access/Step Therapy BOTTOM LINE? Takeda can build a better environment for innovation What WE Accomplish through TakPAC Help ELECT Candidates Build Strong RELATIONSHIPS EDUCATE on Takeda Issues 6

2017 TakPAC FINANCIAL STATEMENT REVENUE Cash on Hand (1/1/2017) $ 19,980.89 Receipts from Voluntary Employee Donations $ 95,648.19 $ 115,629.08 DISBURSEMENTS Federal Candidates & Political Committees $ 84,000.00 Operating Expenses (bank fees) $ 1,871.10 Total $ 85,871.00 Ending Balance (12/31/17) $ 29,758.08 s 7

WHO MAKES THE DECISIONS? 2017 TakPAC Board of Advisors OFFICERS CHAIR VICE CHAIR TREASURER ASST. TREASURER RICHARD ASCROFT LAURA CLINE HELEN GIZA PATRICK BUTLER Sr. Vice President, Managed Markets and Government Affairs Head, Policy and Advocacy Government and External Affairs Sr. Vice President and Chief Financial Officer U.S. Business Unit Head, U.S. Tax MEMBERS Laurene Giagnorio SVP, Human Resources & Administration, U.S. BU Eric Hahn Site Head, Biologics Operations & Engineering, Brooklyn Park Dominika Kovacs Head of Transformation Office, Research & Development Liz Lewis Chief Counsel & Head of Patient Advocacy, Oncology Business Unit Steve Schaefer SVP, General Medicine, U.S. BU Dobson Schofield Head of Compliance, U.S. BU Rahul Singhvi Chief Operating Officer, Vaccine Business Unit David Weitz Head, Takeda California (TCAL) & Global Research Externalization, TCAL/R&D How TakPAC Decides Who to Support Support for innovation and positions on key issues affecting Takeda and our patients; Representation in districts/states where Takeda facilities or employees are located; Leadership position and membership on key committees dealing with issues important to Takeda and our patients; Character, integrity and leadership abilities; and Financial need and nature of the opposition. Political party affiliation or positions on non-business policy issues are not criteria for candidate support. 8

2017 POLITICAL CONTRIBUTIONS TakPAC Contributions to Federal Candidates & Leadership PACs Candidates Party District Amount Alabama Rep. Robert Aderholt R 04 $1,000 California Rep. Grace Napolitano D 36 $1,000 Rep. Scott Peters D 52 $4,000 Rep. Raul Ruiz D 36 $1,000 Rep. Mimi Walters R 45 $1,000 Colorado Sen. Michael Bennet D $1,000 Delaware Sen. Tom Carper D $1,000 Sen. Chris Coons D $1,000 Florida Rep. Carlos Curbelo R 26 $2,000 Hawaii Sen. Mazie Hirono D $1,000 Illinois Rep. Cheri Bustos D 17 $1,000 Rep. Danny Davis D 07 $1,000 Sen. Tammy Duckworth D $1,000 Rep. Robin Kelly D 02 $1,000 Rep. Adam Kinzinger R 16 $1,000 Rep. Darin LaHood R 18 $1,000 Rep. Mike Quigley D 05 $1,000 Rep. Peter Roskam R 06 $2,500 Rep. Brad Schneider D 10 $2,500 Rep. John Shimkus R 15 $1,000 Indiana Rep. Susan Brooks R 05 $1,000 Rep. Larry Bucshon R 08 $1,000 Kansas Rep. Kevin Yoder R 03 $1,000 9

2017 POLITICAL CONTRIBUTIONS Candidates Party District Amount Massachusetts Rep. Mike Capuano D 07 $2,500 Rep. Katherine Clark D 05 $1,000 Rep. Joe Kennedy D 04 $1,000 Sen. Ed Markey D $1,000 Rep. Jim McGovern D 02 $1,000 Rep. Seth Moulton D 06 $1,000 Rep. Richard Neal D 01 $2,000 Minnesota Rep. Erik Paulsen R 03 $2,500 Missouri Sen. Roy Blunt R $1,000 Montana Sen. Heidi Heitkamp D $1,000 New Jersey Rep. Frank Pallone D 06 $1,000 New Mexico Rep. Ben Ray Lujan D 03 $1,000 New York Rep. Lee Zeldin R 01 $1,000 North Carolina Rep. Patrick McHenry R 10 $3,000 Ohio Rep. Pat Tiberi R 12 $5,000 Rep. Brad Wenstrup R 02 $1,000 Oregon Rep. Greg Walden R 02 $5,000 Sen. Ron Wyden D $1,000 Pennsylvania Rep. Ryan Costello R 06 $1,000 Rep. Charlie Dent R 15 $1,000 Rep. Mike Kelly R 03 $1,500 Tennessee Rep. Phil Roe R 01 $1,000 Texas Rep. Kevin Brady R 08 $1,000 Rep. Bill Flores R 17 $1,000 Utah Sen. Orrin Hatch R $1,000 Washington Sen. Patty Murray D $2,500 Rep. Cathy McMorris Rodgers R 05 $1,000 Wisconsin Rep. Ron Kind D 03 $1,000 Total $84,000 10

2017 POLITICAL CONTRIBUTIONS Federal Political Committees Political Affiliation Amount Moderate Democrats PAC D $5,000 New Democrats PAC D $2,500 Republican Main Street Partnership PAC R $2,500 Total $10,000 TakPAC Contribution Limits $5,000 per primary and general election to a federal candidate s campaign committee. $15,000 per calendar year to each national party committee, such as the Democratic and Republican national, senatorial and congressional campaign committees. $5,000 per year to a federal incumbent s leadership PAC. Leadership PACs may be sponsored by Members of Congress to support other candidates from their political party in order to position themselves for future leadership spots or committee chairmanships. These are separate from a member s campaign committee. $5,000 per year to a state or local party committee. Contribution limits for state and local candidates vary by state laws. 11

PUBLIC POLICIES IMPACT PATIENTS AND TAKEDA Takeda s U.S. Government and External Affairs (GEA) staff works to educate state and federal elected officials about issues affecting patients, our products and therapeutic areas, and our company. GEA also advocates for policies that reflect our patient-centric approach, and strives to be the voice for patients in public policy discussions on Capitol Hill and in state capitals across the country. Our elected leaders need to know how their decisions and policies will impact the health of patients in their district or state. The GEA team is committed to providing information to all employees about the public policy issues that impact our company through the GEA pages on MyTakeda. We believe it is important for everyone at Takeda to understand the impact, positive and negative, that public policy decisions have on our company and the patients we serve. EMPLOYEES ENGAGED IN TakPAC CREATE ENVIRONMENT OF INNOVATION TOOLS FOR SUCCESS Environment of Innovation 12

For more information about TakPAC visit contact TakPAC@takeda.com. One Takeda Parkway Deerfield, IL 60015 TakPAC@Takeda.com www.takedapac.com 2017 ANNUAL REPORT