The 1 st International Congress on Controversies in Personalized Oncology Treatment: Breast, Colon, Lung and Melanoma

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The 1 st International Congress on Controversies in Personalized Oncology Treatment Breast, Colon, Lung and Melanoma SPONSORSHIP AND EXHIBITION P r o sp e ctu s Last Update: August 28, 2012 23 www.comtecmed.com/conpo conpo@comtecmed.com

O ver Dear Friends and Colleagues the years, the field of oncology has undergone an enormous expansion in clinical and basic data as well as in field-related technology. New treatment possibilities and advances are being explored in different directions for breast, lung, colon and melanoma cancer. The International Congress on Controversies in Personalized Oncology (CONPO) is intended as an exclusive forum for international experts to share and compare experiences, in order to outline the potentially best treatments for patients within these controversial areas There is little available in the peer-reviewed literature on controversies in personalized oncology, so there is a perceived need to enable an effective debate about unresolved issues, often resulting in agreed-upon answers supported by evidence-based medicine and expert opinion. Participants will have the advantage to discuss and debate these unresolved issues with leading world experts in all fields of oncology. The Congress aims to reach the best answers currently possible and provide the clinician with reliable, up-to-date scientific solutions, based on the best existing evidence. We invite you to take part in The International Congress on Controversies in Personalized Oncology (CONPO), which is intended as the inaugural event of many future editions. We look forward to an exciting event in the beautiful city of Barcelona. Dr. David Sidransky Dr. Lior Soussan-Gutman CONPO co-chairpersons 23

Aims of the Congress To promote excellence in the field of Oncology, by discussing, in a debate forum, evidence-based medicine and expert opinions on current controversial issues To bridge gaps between expansion of basic science and information, and their consolidation into clinical practice To promulgate ethics and standards of practice and treatment To reach consensus on certain controversial issues, through debates, round table discussions and plenary lectures To make it possible for the industry to meet with outstanding experts in the field, and to update international participants on pressing clinical and technological questions of the day The Program Controversial topics Debates and discussions on unresolved controversies Cohesive and integrative sessions World eminent speakers Audience/speaker discussions Continuing Medical Education (CME)-approved program 3

CO-CHAIRPERSONS David Sidransky, USA Lior Soussan-Gutman, Israel Alberto Bardelli, Italy David Beer, USA Hal Burstein, USA George Demetri, USA Manel Esteller, Spain Faculty Fred Hirsch, USA Howard Hocehster, USA David James, USA Matthew Meyerson, USA Klaus Pantel, Germany Rafael Rosell, Spain Yehuda Shenfeld, Israel David Sidransky, USA David B. Solit, USA Victor Velcelescu, USA Timothy Yap, UK 4

17:00-19:00 Plenary Session & Opening Ceremony 19:00 Welcome reception TIMETABLE Thursday, March 7, 2013 Friday, March 8, 2013 Saturday, March 9, 2013 Sunday, March 10, 2013 Predictive Biomarkers, Pathways & Targeted Therapy 08:30-10:00 Session 1 Session 5 09:00-10:30 Session 9 08:30-09:15 Educational - Common Educational session describing Predictive biomarkers in whole genome vs. selected multiple cancer types genes panel approach A. Bardelli, Italy M. Meyerson, USA 09:15-10:00 Educational - The EGFR story Is it prime time for use of NGS in NSCLC in the clinic R. Rosell, Spain V. Velcelescu, USA 10:00-10:30 Coffee Break 10:30-11:00 Coffee Break 10:30-12:00 Session 2 Session 6 11:00-12:00 Session 10 10:30-11:00 Educational - The ALK story Epigenetics approach - Technical in NSCLC and clinical implications D. Beer, USA M. Esteller, Spain 11:00-11:30 Debate - Pathology histology Predictive biomarkers in GBM vs. Molecular DX in Lung cancer D. James, USA F. Hirsch, USA 11:30-12:00 Educational - The BRAF story Anti CTL-4 mechanism and in Melanoma therapeutic application TBA Y. Shenfeld, Israel 12:00-13:00 Lunch Break 13:00-14:30 Session 3 Session 7 13:00-13:30 mtor mechanism - Signaling Educational - Early breast and therapeutic application cancer signatures across disease H. Burstein, USA TBA 13:30-14:00 Educational - The HER2 story Educational - Early colon in Breast cancer signatures H. Burstein, USA H. Hocehster, USA 14:00-14:30 Mechanism of MAPK Pathway CTC as prognostic / monitoring targeting and resistance tool in epithilial solid tumors D.B. Solit, USA K. Pantel, Germany 14:30-15:00 Coffee Break Advanced Molecular Technologies in Service of Personalized Oncology 15:00-17:00 Session 4 Session 8 15:00-15:30 GIST: C-KIT PDGFR roadmap for In-vivo modeling for drug activating and resistant sensitiviy approach mutations in GIST D. Sidransky, USA G. Demetri, USA 15:30-16:00 Educational- PARP Mechanism Past vs. future and implications of action for clinical trial design in T. Yap, UK molecular dx era TBA 16:00-17:00 Panel: Small molecules vs. abs - Panel: Technologies in service Debate session of the oncologist Moderator: A. Bardelli, Italy Moderator: TBA Panelists: Panelists: D. Beer, USA H. Burstein, USA H. Burstein, USA M. Esteller, Spain G. Demetri, USA H. Hocehster, USA F. Hirsch, USA D. James, USA R. Rosell, Spain M. Meyerson, USA D.B. Solit, USA K. Pantel, Germany T. Yap, UK Y. Shenfeld, Israel D. Sidransky, USA V. Velcelescu, USA 5 TBA

CATEGORIES OF SPONSORSHIP Platinum 50,000-75,000 GOLD 25,000-50,000 SILVER 10,000-25,000 Sponsor 2,000-10,000 6

Scientific sponsorship OpportunitIES Continuing medical education (CME) Approved SESSION 40,000 An unrestricted grant to support an existing session, or to suggest a CME-approved session as part of the Scientific Program. Educational Session Session hall and basic audiovisual equipment Complimentary registrations for Session Chairpersons and Speakers Five complimentary registrations Exhibition 12 sq.m exhibition space (additional space available at 300 per sq.m) Two exhibitor registrations (additional registrations available at reduced rates) Advertisement Package One full page color advertisement in the Congress Program Book Brochure in the participants' bags Promotion Optional webcast of Session at discounted rates Company logo on regular announcements to Congress Database PRESENTATION IN THE Continuing medical education (CME) Approved PRogram 25,000 An unrestricted grant to support a presentation in an existing session in the CME-approved scientific program. Educational Session Session hall and basic audiovisual equipment Complimentary registrations for presentation Speakers Exhibition 6 sq.m exhibition space (additional space available at 300 per sq.m) Two exhibitor registrations (additional registrations available at reduced rates) Advertisement Package One full page color advertisement in the Congress Program Book Brochure in the participants' bags Promotion Optional webcast of Session at discounted rates Company logo on regular announcements to Congress Database 7

Scientific sponsorship OpportunitIES NEW PLAYERS ON THE BLOCK 10,000 A 10-15 minute presentation on a new drug/product to be included in the New Players Session as part of the Scientific Program. Session hall and basic audiovisual equipment Brochure in the participants bags The expenses (travel, accommodation and registration) of the Chairpersons and Speaker/s of a New Players on the Block Presentation are additional, and the responsibility of the Sponsor. EUROPEAN SPEAKER 3,000 An unrestricted grant to cover, in part, the expenses of one invited European Speaker. Expenses include travel, accommodation and registration. One full page color advertisement in the Congress Program Book NON-EUROPEAN SPEAKER 6,000 An unrestricted grant to cover, in part, the expenses of one invited non-european Speaker. Expenses include travel, accommodation and registration. One full page color advertisement in the Congress Program Book 8

Scientific sponsorship OpportunitIES PRIZES FOR OUTSTANDING ABSTRACTS 4,000 Prizes will be awarded to the authors of the most outstanding abstracts/posters, as chosen by the Congress Chairpersons. Company representatives will be invited to attend the Award Ceremony LUNCH 25,000 (per lunch) Opportunity to subsidize, in part, a buffet lunch to be served to all participants of the Congress. Two complimentary registrations One full page color advertisement in the Congress Program Book Brochure in the participants bags 9

sponsorship OpportunitIES WELCOME RECEPTION 10,000 A Welcome Reception for all participants will be held on Thursday evening. Two complimentary registrations Company logo on the official invitation Acknowledgment on special board on-site during the Welcome Reception One full page color advertisement in the Congress Program Book Brochure in the participants bags FACULTY DINNER 15,000 A dinner will be held for the invited Speakers of the Congress. Two complimentary registrations Company logo on the official invitation One full page color advertisement in the Congress Program Book Brochure in the participants bags CONGRESS PROGRAM BOOK 15,000 The Congress Program Book will include the Scientific Program and the Scientific Abstracts, and will be distributed to all participants. Full page color advertisement on the back cover of the Congress Program Book Additional full page color advertisement in the Congress Program Book 10

sponsorship OpportunitIES INTERNET CENTER 10,000 The Internet Center will be outfitted with internet workstations for participants of the Congress to stay updated between sessions. The Sponsor may: Display logo as a screensaver Display logo on screen background PARTICIPANTS BAGS provided-in-kind + 10,000 The opportunity to provide branded bags for all participants of the Congress. Brochure in the participants bags 11

sponsorship OpportunitIES POCKET PROGRAM 5,000 A Pocket Program will be distributed to all participants in their Congress Kits. Exclusive advertisement on the back cover of the Pocket Program Brochure in the participants bags WRITING PADS AND PENS provided-in-kind + 5,000 The opportunity to provide branded writing pads and pens that will be included in the participants bags. CONGRESS LANYARDS The Sponsor will provide printed lanyards for the name badges 5,000 The Congress will provide printed lanyards for the name badges 8,000 This sponsorship opportunity is reserved for Platinum and Gold Sponsors, and will be available on a firstcome, first-served basis. 12

sponsorship OpportunitIES BROCHURE INSERT 3,000 Company brochure to be inserted into the participants bags, which will be distributed at the Congress. COFFEE BREAK 3,000 (per coffee break) There will be daily coffee breaks between sessions throughout the Congress. TAILOR-MADE SPONSORSHIP PACKAGES Sponsorship packages may be tailored to suit the Sponsor s marketing strategy in order to maximize visibility, and to best promote products and services. Please contact the Congress Organizer for further details on creating the appropriate package. 13

EXHIBITION An exhibition will be held in conjunction with the Congress. The exhibition floorplan is designed to maximize exposure to the participants. All lunches and coffee breaks will be held in the exhibition area. Exhibition space will be available on a first-come, first-served basis, with priority given to Platinum and Gold Sponsors. Exhibition space will be available at 500 per sq.m. The minimum booth size is 2x3 sq.m. Please visit www.comtecmed.com/conpo to view the exhibition floorplan. Exhibition space rental is priced according to size (per sq.m) and includes: Net stand area Company profile in Congress Program Book Two exhibitor registrations Exhibitors Manual General cleaning of public areas Venue security Stand equipment and additional services may be ordered by means of the forms in the Exhibitors Manual: Furniture, partition walls, carpets, telephone and data lines, electricity, stand cleaning, exhibitors insurance, logistics, etc. 14

General Information Venue Princessa Sofia Hotel, Barcelona Plaza Pius XII, 4 Barcelona 08028, Spain Tel: +34 93 508 1000 Fax: +34 93 508 1001 Website: www.princesasofia.com Language The official language of the Congress is English. Congress Organizer and Sponsorship / Exhibition Contact: 53, Rothschild Boulevard, PO Box 68 Tel Aviv, 6100001, Israel Tel: +972 3 5666166 Fax: +972 3 5666177 E-mail: conpo@comtecmed.com Website: www.comtecmed.com/conpo Liability and Insurance The organizer carries no liability whatsoever for injuries or damages involving persons and/or property during the Congress. Participants are advised to issue their own personal travel and health insurance for their trip. Terms and Conditions: All sponsorship and exhibition prices quoted are in and are subject to VAT Time slot allocation will be based on level of sponsorship and approval from the Scientific Committee It is the responsibility of the Sponsors and Exhibitors to comply with the regulations of the local authorities, EFPIA (European Federation of Pharmaceutical Industries & Associations) www.efpia.org and IFMPA (International Federation of Pharmaceutical Manufacturers & Associations) www.ifpma.org Code of Practice on the Promotion of Medicines. The Congress Organizer reserves the right to accept or decline offers of sponsorship and application for exhibition space The Congress Organizer reserves the right to amend the published floorplan should it be deemed necessary for the benefit the exhibition and the Congress as a whole Please note that the Congress Organizer must approve all exhibition stand designs 15

The 1 st International Congress on Controversies in Personalized Oncology Treatment Breast, Colon, Lung and Melanoma www.comtecmed.com/conpo conpo@comtecmed.com 23