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THE ACADEMY FOR CLINICAL DEBATES & CONTROVERSIES IN MEDICINE The 4th World Congress on CONTROVERSIES TO CONSENSUS IN DIABETES, OBESITY AND HYPERTENSION SPONSORSHIP & EXHIBITION PROSPECTUS Last Update: September 6, 2011 www.codhy.com codhy@codhy.com

Dear Colleagues and Friends, We are delighted to announce the 4th World Congress on Controversies to Consensus in Diabetes, Obesity, and Hypertension (CODHy) which will take place on November 15 18, 2012. The CODHy Congress gathers prominent global experts for engaging discussions, information sharing, and experience-based perspectives. The Congress serves as a dynamic forum which promotes productive clinical debates between practicing physicians and researchers on the critical issues within the fields of diabetes, obesity, and hypertension today. The Congress prides itself on having the most up-to-date clinical, scientific, and academic program, concentrating not only on future therapies and interventions, but also on disease prevention and treatment goals. The World CODHy Congress was established in 2006; following its unprecedented success, it has expanded to include regional congresses in Latin America and Asia Pacific. As in previous years, the proceedings of this World CODHy Congress will be published in a special supplement of the Diabetes Care Journal featuring peer-reviewed articles by CODHy s prestigious speakers. The most recent edition of this supplement can be found online as well: http://care.diabetesjournals. org/content/34/supplement_2?etoc We invite you to join us for an exceptional Congress, providing participants and speakers alike with the unique opportunity to debate the most pressing issues in diabetes, obesity, and hypertension. As always, there are a number of sponsorship opportunities available, including industry-sponsored activities. In addition, we would be happy to tailor a sponsorship package to your specific needs. We look forward to your participation. Sincerely, Prof. Stefano Del Prato and Prof. Itamar Raz Co-Chairpersons

AIMS OF THE CONGRESS To promote excellence in the fields of Diabetes, Obesity and Hypertension, by discussing, in a debate forum, evidence-based medicine and expert opinions on current controversial issues To bridge gaps between expansion of basic science and information, and their consolidation into clinical practice To promulgate ethics and standards of practice and treatment To reach consensus on certain controversial issues, through debates, round table discussions and plenary lectures To make it possible for the industry to meet with outstanding experts in the field, and to update international participants on pressing clinical and technological questions of the day PAST WORLD CONGRESSES AND STATISTICS Berlin 2006 Barcelona 2008 Prague 2010 Sessions 26 27 27 Debates 9 13 18 Faculty 143 136 84 Poster Abstracts 138 99 143 Countries 66 83 69 DEMOGRAPHICS 3

CO-CHAIRPERSONS Prof. Stefano Del Prato Prof. Itamar Raz ORGANIZING COMMITTEE J. Chan, China (HK) J. Davidson, USA R.A. DeFronzo, USA E. Grossman, Israel P. Home, UK M. Laakso, Finland L.A. Leiter, Canada E. Standl, Germany L. Van Gaal, Belgium A. Avogaro, Italy R.G. Bretzel, Germany A. Ceriello, UK S. Cernea, Romania J.H. de Vries, The Netherlands D. de Zeeuw, The Netherlands M. Donath, Switzerland M.O. Federici, Italy B. Frier, Scotland B. Gallwitz, Germany A.J. Garber, USA V. Hainer, Czech Republic Y. Handelsman, USA M. Hanefeld, eld, Germany SCIENTIFIC COMMITTEE (Preliminary List) T.A.M. Heagerty, UK L. Heinemann, Germany S. Heller, UK B. Hirshberg, USA P. Iozzo, Italy L. Ji, China N.M. Lalic, Serbia H. Lebovitz, USA R. Lichiardopol, Romania G. Mancia, Italy M.A. Nauck, Germany A. Nicolucci, Italy P.M. Nilsson, Sweden G. Ning, China G. Perseghin, Italy P. Pozzilli, Italy E. Ravussin, USA F. Rubino, USA L.M. Ruilope, Spain G. Schernthaner, Austria I. Shai, Israel J. Škrha, Czech Republic A. Solini, Italy I. Tkac, Slovakia H. Toplak, Austria D. Tschöpe, Germany C. Tsigos, Greece J. Tuomilehto, Finland J. Wainstein, in, Israel

PRELIMINARY SCIENTIFIC PROGRAM FRIDAY, NOVEMBER 16, 2012 HALL A HALL B HALL C 08:30-10:00 PLENARY SESSION 1 BREAKTHROUGHS IN DIABETES IN 2012 Breakthroughs in diabetes Insulin resistance: A multifaceted disease responsible for ASCVD and cancer Diabetes, obesity and cancer Diabetes/hypertension therapy and cancer 10:00-10:30 Coffee Break 10:30-12:00 SESSION 2 SESSION 5 SESSION 8 Old vs. New therapy HYPERTENSION OBESITY in early diabetes CONTROVERSIES New developments in Pro Old/Pro New Should we change the obesity Present vs. future insulin target blood pressure in Do we need anti-obesity analogues diabetic patients? drugs or lifestyle Present/Future Yes/No intervention only? Blood pressure (BP) Anti-obesity drugs/ variability or average BP Lifestyle intervention only to determine future Cardiovascular (CV) outcome BP variability/average BP 12:00-13:30 Lunch Break 13:30-15:30 SESSION 3 SESSION 6 SESSION 9 Starting insulin therapy OBESE VS. NORMAL TARGETING THE KIDNEY by GP: BASAL vs. Premix WEIGHT The kidney and the role Insulin intensification The Obesity Paradox in of SGLT2 in Glucose by GP coronary disease Homeostasis Yes/No Is obesity a brain disease? Glucosuria as a novel Yes/No approach in diabetes Does weight loss management mechanism influence SGLT2 safety barriers metabolic outcome? Yes/No 15:30-16:00 Coffee Break 16:00-17:30 SESSION 4 SESSION 7 SESSION 10 DIABETES AND SLEEP BARIATRIC SURGERY MEET THE PROFESSOR DISORDER: RELATION Minimal requirements to Postprandial TO OBESITY AND perform bariatric surgery hyperglycaemic variability: HYPERTENSION Do we have long term Should we care? data to support efficacy Yes/No and safety? Yes/No Surgery in mild obesity 1 st line/ 2 nd line Surgery during adolescence Yes/No SATURDAY, NOVEMBER 17, 2012 HALL A HALL B HALL C 08:30-10:00 SESSION 11 SESSION 15 SESSION 19 TYPE 2 DIABETES (T2D) NEW TREATMENT ALGORITHM A1C target or an Can we stop beta cell Barrier to intensification individual approach destruction? of diabetes therapy Different goals with Yes/No Yes/No different treatment: Early insulin therapy Rethinking the target The role of new insulin/ Yes/No algorithm GLP1 analogue Old/New What can we learn from new outcome studies? 10:00-10:30 Coffee Break 5

PRELIMINARY SCIENTIFIC PROGRAM SATURDAY, NOVEMBER 17, 2012 HALL A HALL B HALL C 10:30-12:00 SESSION 12 SESSION 16 SESSION 20 GLP1/DPP4: Are they THE UNSOLVED PROBLEM PATIENT APPROACH safe? OF HYPOGLYCAEMIA Should it be mainly based Short term safety/long Good or Bad? on Evidence-Based term safety Similar importance for Medicine (EBM) Extra pantriact effect every patient? Yes/No of incretin therapy Yes/No Based on meta analysis Can it be prevented? and health-care data Yes/No Yes/No 12:00-13:30 Lunch Break 13:30-15:30 SESSION 13 SESSION 17 SESSION 21 FUTURE LONG ACTING DIABETES, OBESITY AND FUTURE THERAPY FOR ANALOGUES: ARE THEY HYPERTENSION IN DIABETES ADVANTAGEOUS? ELDERLY PATIENTS GLP1 Glucagon GLP1 Is there a different target? combination Yes/No Obesity GPR40 and GPR119 Insulin Diabetes 11-beta hyroxysteriod Yes/No Hypertension Protein tyrosine phosphatase 15:30-16:00 Coffee Break 16:00-17:30 SESSION 14 SESSION 18 SESSION 22 CLINICAL DEVELOPMENT DIABETES TREATMENT HYPERTENSION OF ANTI-DIABETIC Role of physical exercise Should we target AGENTS: WORLDWIDE Pro/Con subclinical organ damage? AND REGIONAL Role of diet Yes/No Pro/Con Hypertension without Nephropathy: 1 st line therapy RAAS blocked/any drug SUNDAY, NOVEMBER 18, 2012 HALL A 08:30-10:00 PLENARY SESSION 23 Management of atherogenic displidiemia in T2D Intolerance to statin/target HDL Yes/No 10:00-10:30 Coffee Break 10:30-12:00 PLENARY SESSION 24 FUTURE THERAPY Phase 2/3 drugs in development Future therapy for obesity and diabetes: Long acting GLP1/ Insulin Safety outcome studies vs. healthcare data base 6

CATEGORIES OF SPONSORSHIP PRESIDENTIAL CIRCLE 85,000 + PLATINUM 60,000 85,000 GOLD 40,000 60,000 SILVER 20,000 40,000 BRONZE 10,000 20,000 SPONSOR 2,000 10,000 7

SCIENTIFIC SPONSORSHIP OPPORTUNITIES CONTINUING MEDICAL EDUCATION (CME) APPROVED SESSION 40,000 An unrestricted grant to support an existing session, or to suggest a CME-approved session (60-90 minutes) as part of the Scientific Program. Educational Session Session hall and basic audiovisual equipment Four complimentary registrations for Session Chairpersons and Speakers Exhibition 6 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) Advertisement Package One full page color advertisement in the Congress Program Book Brochure in the participants bags Promotion Optional webcast of Session at discounted rates Company logo on regular announcements to Congress Database The expenses (travel, accommodation and registration) of the Chairpersons rsons and Speakers of a supported CME-approved session are additional and the responsibility of the Sponsor.

SCIENTIFIC SPONSORSHIP OPPORTUNITIES PRE-CONGRESS SATELLITE SYMPOSIUM (NON-CME APPROVED) 60,000 An industrial non-cme-approved Pre or Post-Congress Satellite Symposium (3-4 hours). This option is particularly suited for drug launching and other special events. Educational Session Symposium hall and basic audiovisual equipment Six complimentary registrations Exhibition 12 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) Advertisement Package One full page color advertisement in the Congress Program Book Brochure in the participants bags Promotion Optional webcast of Symposium at discounted rates Company logo on regular announcements to Congress Database Specially-designed mailshots announcing Industrial Satellite Symposium to Sponsor s subsidiaries and affiliates The expenses (travel, accommodation and registration) of the Chairpersons and Speakers of an Industrial Pre or Post-Congress Satellite Symposium are additional and the responsibility of the Sponsor. EUROPEAN SPEAKER 3,000 An unrestricted grant to cover, in part, the expenses of one invited European Speaker. Expenses include travel, accommodation and registration. One full page color advertisement in the Congress Program Book 9

SCIENTIFIC SPONSORSHIP OPPORTUNITIES NON-EUROPEAN SPEAKER 6,000 An unrestricted grant to cover, in part, the expenses of one invited non-european Speaker. Expenses include travel, accommodation and registration. One full page color advertisement in the Congress Program Book PRIZES FOR OUTSTANDING ABSTRACTS 4,500 Prizes will be awarded to the authors of the most outstanding abstracts/posters, as chosen by the Congress Chairpersons. Company profile in the Congress Program Book Acknowledgment: Congress Website, Congress Program Book, on-site Signage Company representatives will be invited to attend the Award Ceremony

SPONSORSHIP OPPORTUNITIES LUNCH 25,000 (per lunch) An opportunity to subsidize, in part, a buffet lunch to be served to all participants of the Congress. This sponsorship opportunity is reserved for Platinum or Gold Sponsors, and will be available on a first-come, first-served basis. Four complimentary registrations One full page color advertisement in the Congress Program Book Brochure in the participants bags WELCOME RECEPTION 25,000 A Welcome Reception for all participants will be held on Thursday evening. Two complimentary registrations 5-minute greeting at the Welcome Reception Company logo on the official invitation Acknowledgment on special board on site during the Welcome Reception One full page color advertisement in the Congress Program Book Brochure in the participants bags FACULTY DINNER 20,000 A dinner will be held for the invited Speakers of the Congress. Two complimentary registrations 5-minute greeting at the Faculty Dinner Company logo on the official invitation Acknowledgment on special board on site during the Faculty Dinner One full page color advertisement in the Congress Program Book Brochure in the participants bags 11

SPONSORSHIP OPPORTUNITIES CONGRESS PROGRAM BOOK 15,000 The Congress Program Book will include the Scientific Program and the Scientific Abstracts, and will be distributed to all participants. Full page color advertisement on the back cover of the Congress Program Book Additional full page color advertisement in the Congress Program Book INTERNET CENTER 10,000 The Internet Center will be outfitted with internet workstations for participants of the Congress to stay updated between sessions. THE SPONSOR MAY: Display logo as a screensaver Display logo on screen background PARTICIPANTS BAGS provided-in-kind + 10,000 The opportunity to provide branded bags for all participants of the Congress. Brochure in the participants bags 12

SPONSORSHIP OPPORTUNITIES CONGRESS ABSTRACTS ON THE WEBSITE 10,000 The Scientific Abstracts of the Congress will be placed on the Congress Website and will be available for a limited period. POCKET PROGRAM 8,000 A Pocket Program will be distributed to all participants in their Congress Kits. Exclusive advertisement on the back cover of the Pocket Program Brochure in the participants bags TRANSLATION 5,000 (per hall, per day) Simultaneous translation into any required language. WRITING PADS AND PENS provided-in-kind + 5,000 The opportunity to provide branded writing pads and pens that will be included in the participants bags. 13

SPONSORSHIP OPPORTUNITIES CONGRESS LANYARDS The Sponsor will provide printed lanyards for the name badges 5,000 The Congress will provide printed lanyards for the name badges 8,000 This sponsorship opportunity is reserved for Presidential Circle and Platinum Sponsors, and will be available on a first-come, first-serve basis. BROCHURE INSERT 3,000 Company brochure to be inserted into the participants bags, which will be distributed at the Congress. COFFEE BREAK 3,000 (per coffee break) There will be daily coffee breaks between sessions throughout the Congress. TAILOR-MADE SPONSORSHIP PACKAGES Sponsorship packages may be tailored to suit the Sponsor s marketing strategy in order to maximize visibility, and to best promote products and services. Please contact the Congress Organizer for further details on creating the appropriate package. 14

EXHIBITION An exhibition will be held in conjunction with the Congress. The exhibition floorplan is designed to maximize exposure to the participants. All lunches and coffee breaks will be held in the exhibition area. Exhibition space will be available on a first-come, first-served basis, with priority given to Presidential Circle and Platinum Sponsors. Exhibition space will be available at 800 per sq.m. The minimum booth size is 2x3 sq.m. Please visit www.codhy.com to view the exhibition floorplan. Exhibition space rental is priced according to size (per sq.m) and includes: Net stand area Company profile in Congress Program Book Two exhibitor registrations Exhibitors Manual General cleaning of public areas Venue security Stand equipment and additional services may be ordered by means of the forms in the Exhibitors Manual: Furniture, partition walls, carpets, telephone and data lines, electricity, stand cleaning, exhibitors insurance, logistics, among other services. TERMS AND CONDITIONS All sponsorship and exhibition prices quoted are in and are subject to VAT Time slot allocation will be based on level of sponsorship and approval from the Scientific Committee It is the responsibility of the Sponsors and Exhibitors to comply with the regulations of the local authorities, EFPIA (European Federation of Pharmaceutical Industries & Associations) www.efpia.org and IFMPA (International Federation of Pharmaceutical Manufacturers & Associations) www.ifpma.org Code of Practice on the Promotion of Medicines. The Congress Organizer reserves the right to accept or decline offers of sponsorship and application for exhibition space The Congress Organizer reserves the right to amend the published floorplan should it be felt that such an amendment would benefit the exhibition and the Congress as a whole Please note that the Congress Organizer must approve all exhibition stand designs 15

THE ACADEMY FOR CLINICAL DEBATES & CONTROVERSIES IN MEDICINE The 4th World Congress on CONTROVERSIES TO CONSENSUS IN DIABETES, OBESITY AND HYPERTENSION GENERAL INFORMATION LANGUAGE The official language of the Congress is English. REGISTRATION Early Registration Late Registration From until from November 8, 2012 August 15, 2012 August 16, 2012 & On Site Participants - 540 590 650 Physicians and Scientists Residents* 380 430 470 Nurses and Students 190 240 250 Accompanying Persons 140 * Refers to non-tenured junior scientists. Registration form must be accompanied by documentation of residency or a letter from the head of department confirming their status. The letter should be on the department letterhead and addressed to the Registration Department of the Congress. CONGRESS ORGANIZER AND SPONSORSHIP / EXHIBITION CONTACT: ComtecMed 53, Rothschild Boulevard, PO Box 68 Tel Aviv, 61000, Israel Tel: +972 3 5666166 Fax: +972 3 5666177 Contact: Lynn Skulnik, Industry Liaison Manager E-mail: Lynn@comtecmed.com Website: www.codhy.com LIABILITY AND INSURANCE The organizer carries no liability whatsoever for injuries or damages involving persons and/or property during the Congress. Participants are advised to issue their own personal travel and health insurance for their trip. www.codhy.com codhy@codhy.com