Constitution of the ISPOR Regional Chapter SPAIN

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Constitution of the ISPOR Regional Chapter SPAIN Article 1: Name 1. International Society of Pharmacoeconomics and Outcomes Research Spain Regional Chapter, herein referred to as ISPOR-SPAIN or the ISPOR Spain Chapter. 2. Address Instituto de Salud Carlos III, C/ Sinesio Delgado, 10 28029 de Madrid. Article 2: Mission The mission of the ISPOR SPAIN is to: 1. Provide an environment where researchers, health care practitioners, and decision-makers interested in pharmacoeconomics and outcomes research can share knowledge at a country level. 2. Serve as a bridge in bringing together country researchers, health care practitioners, and decision-makers interested in pharmacoeconomics and members of the pharmaceutical industry, health-related organizations, and academia. 3. Act as a resource at a local level for individuals interested in pharmacoeconomics and outcomes research. 4. Provide an opportunity for country-specific chapter members to become more familiar with the activities of ISPOR as well as participate in its activities. Article 3: Affiliation 1. This ISPOR-SPAIN will maintain affiliation as a component chapter of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR). Article 4: Membership 1. Active membership is open to any individual (in the country) interested in the Society and who supports the mission of the Society. 2. The eventual yearly dues for local members will be defined yearly by the ISPOR SPAIN Chapter Executive Committee. 3. This is the current list of ISPOR SPAIN Chapter members

1. Álvaro Hidalgo (Universidad Castilla La Mancha) 2. Amaya Echevarria (Sanofi-aventis) 3. Antoni Sicras (Badalona Serveis Assistencials) 4. Antonio Castro (Roche) 5. Antonio Ramirez-Arellano (Bristol-Myers) 6. Belén Martí (Pfizer) 7. Carlos Crespo (Oblikue Consulting, Universidad Autónoma de Barcelona) 8. Carlos Polanco (Merck) 9. Carlos Rubio (Hero Consulting) 10. Carme Piñol (Bayer) 11. Carmen Valentín (Allergan) 12. Concha Alvarez (AstraZeneca) 13. Cristina Sánchez Maestre (Roche) 14. Cristina Varela (Roche) 15. Desiré Rodríguez (Medtronic) 16. Elena Ruiz-Beato (Roche) 17. Elisa Hernández Torres (Hospital Virgen de las Nieves) 18. Enrique Antón de las Heras (Medtronic) 19. Gonzalo Nocea Pulfer (Merck sharp & dohme) 20. Guillermo Villa (Baphealth) 21. Iñigo Gorostiza (Dirección de Farmacia. Departamento de Sanidad. Eusko Jaurlaritza - Gobierno Vasco) 22. Isabel Pérez (GlaxoSmithKline) 23. Itziar Oyagüez (PORIB) 24. Javier Rejas (Pfizer) 25. Javier Soto (Pfizer) 26. Jesús Cuervo (Baphealth) 27. Jordi Garlera (Novartis) 28. José Manuel Rodríguez (Johnson & Jonson) 29. Josep Fortea (Almirall) 30. Josefina Velasco (Boehringer Ingelheim) 31. Juan Manuel Collar 32. Juan Manuel Collar (Grünenthal) 33. Juan Oliva (Universidad Castilla La Mancha) 34. Julio López Bastida (SCS--Servicio de. Evaluación y Planificación) 35. Laura Delgado Ortega (AstraZeneca) 36. Laura Gutiérrez (AMGEN) 37. Louder Betegon (Sanofi-aventis) 38. Luis Lizán (Outcomes 10, Universidad Jaume I) 39. Mª José Chincolla (Esteve) 40. MªAmparo Valladares (Lilly) 41. Margarita Capel (AstraZeneca) 42. María Costi (Lilly) 43. Marta Rubio (Almirall) 44. Max Brossa (Oblikue Consulting) 45. Mercedes García (Pfizer) 46. Miguel Angel Casao (PORIB)

47. Montse Figuerras (Novartis) 48. Nuria González-Rojas (Boehringer Ingelheim) 49. Olga Espallardo (Merck) 50. Pablo Guijarro (Wyeth) 51. Pablo Repollo (Baphealth) 52. Paloma González (Medtronic) 53. Pedro Gómez Pajuelo (Instituto de Salud Carlos III) 54. Pedro Serrano (SCS--Servicio de. Evaluación y Planificación) 55. Raquel Lahoz (Novartis) 56. Raúl Morano (GlaxoSmithKline) 57. Ruth Navarro (Hospital Germans Trias i Pujol) 58. Silvia Paz (Outcomes 10, Universidad Jaume I) 59. Tatiana Dilla (Lilly) 60. Teresa Caloto (Merck sharp & dohme) 61. Victoria Martín-Escudero (Roche) 4. At least three of the officers will be ISPOR members. 5. This is the current list of ISPOR Spain Chapter members who are also members of ISPOR Olga Espallardo, Merck. ISPOR number 10998. José Manuel Rodriguez, Jonson & Jonson. ISPOR number 6342 Carme Piñol, Bayer Health Care. ISPOR number 5718 6. There will be an ongoing membership recruitment program to encourage membership into the Chapter as well as the Society. Article 5: Organization 1. The ISPOR Spain Chapter shall be composed of: Founding Partners (the signatories of the Constitutive Act of Spanish Chapter) and Full members (partners that submit a written request signed by the applicant stating their name, nationality, age and address. And signed by two Full members as presenters) The ISPOR Spain Executive Committee is composed by the following officers: President, President-elect, Secretary/Treasurer and Leader of specific working areas. The duties and responsibilities should be as defined in Article 7. 2. The current 1st term Executive Committee: President: José Manuel Rodriguez, Health Economics & Reimbursement Director. EMEA Region at Ortho Clinical Diagnostics President-elect: Jaume Puig (Director of the Research Center for Economy and Health; Pompeu Fabra University)

Secretary/Treasurer: Olga Espallardo, Senior Health Economics and Outcomes Research Manager Merck KGa. Leader of specific working areas: Relationships ISPOR Working Groups: Javier Mar (Coordinator of the Interhospital Research Guipuzcoa West Unit, Hospital Alto Deba) Comunications: Carme Piñol (Market Access Manager at Bayer HealthCare). Government affairs: Dr. Pedro Gómez Pajuelo (Deputy Director General of Instituto de Salud Carlos III). Continuing education: Olga Espallardo (Senior Manager Health Economics and Outcomes Research at Merck KGa). 4. The active members of ISPOR Spain should elect the ISPOR Spain Executive Committee officers. Elections should be held at the same time each three years according to the rules and procedures outlined in Article 8. 5. The ISPOR Spain executive officers should hold their respective positions for a term of three years, or for the remainder of a term when filling a vacancy. Article 6: Procedures 1. ISPOR Spain should be governed by this constitution. 2. ISPOR Spain should be a recognized organization in the country and comply with local governmental policies. 3. ISPOR Spain should hold general meetings during the year. Special executive meetings should be held at the discretion of the executive officers. 4. Any member or officer of ISPOR Spain may initiate a constitutional amendment. Procedures for amending this Constitution are outlined in Article 9. 5. Each ISPOR Spain executive officer or member should exercise one vote. 6. The Ordinary General Assembly a proposal of the ISPOR Spain Executive Committee (ISEC) shall fix fees payable by members, as collection and any changes in its size.

7. In the case that the ISEC, fix fees payable by members, the Member who ceases to pay the amount of two installments will be invited to make payment within fifteen days following the request and if it does not, membership will be revoked. 8. The members will ultimately be discharged for the following reasons: For voluntary resignation. In this case again to enter will require the agreement of the General Assembly, having examined the causes that led to the voluntary resignation. Those who perform an act considered by the Board, within or outside the Association, to injure the reputation or prestige of this, and those otherwise prejudice the interests of the same. Those who disobey the decisions of the General Assembly or the Board. Article 7: Duties of Officers Each officer should be elected for a term of three years. President The President of ISPOR Spain should: 1. Conduct and preside over all meetings of ISPOR Spain. 2. Represent ISPOR Spain when called upon to do so. 3. Appoint an individual to any office that becomes vacant subject to the ISPOR Spain Executive Committee approval. 4. The office of the President should be open to any member of ISPOR Spain. 5. Provide a report of activities and financial transaction to the ISPOR Board of Directors annually. President-elect The President-elect of ISPOR Spain should: 1. Succeed to the office of the President upon completion of a three years term of President-elect. 2. Conduct and preside over all meetings of ISPOR Spain in the absence of the President. 3. Assist the President with the responsibilities of ISPOR Spain. 4. The office should be open to any member of ISPOR Spain.

Secretary/Treasurer The Secretary of ISPOR Spain should: 1. Record the minutes of ISPOR Spain meetings. An official copy of the minutes should be kept in the ISPOR Spain records and a copy mailed to the ISPOR Executive Director at: ISPOR, 3100 Princeton Pike Building 3E, Lawrenceville, NJ, USA 08648 or email to: regionalchapter@ispor.org 2. Handle ISPOR Spain correspondence as necessary 3. Be responsible for any financial transactions of ISPOR Spain. 4. Keep and maintain the ISPOR Spain records. 5. Keep and make available to the members of ISPOR Spain and the ISPOR Board of Directors a record of all monies received and spent by ISPOR Spain. 6. Report the financial status of ISPOR Spain at meetings. 7. Assist the President in the preparation of an annual budget. 8. Oversee the financial activities of ISPOR Spain. 9. The office should be open to any member of ISPOR Spain. Leader of specific working areas The number of Leader of specific working areas will be determinate by the President criteria s. Article 8: Election Procedures 1. The active members of ISPOR Spain should elect the ISPOR Spain executive officers. 2. The ISPOR Spain Executive Committee (President, President-elect, and Secretary/Treasurer, leader of specific working areas) should appoint an Election Committee. 3. The Election Committee should solicit nominations. 4. Elections should be held. 5. The new ISPOR Spain President should inform the ISPOR Board of Directors of the newly elected officers. The names of the newly elected officers should be sent to the ISPOR office at: ISPOR, 3100 Princeton

Pike Building 3E, Lawrenceville, NJ, USA 08648 or email to: regionalchapter@ispor.org. Article 9: Termination of Chapter Membership Members will be caused to leave the Chapter for any of the following reasons: 1.- For some action that could be considered objectionable and against the interests and purposes of this chapter. The member would receive a notice with the report of the Executive Committee; there would be an open and secret voting with qualified majority. 2.- In the case of calling for payments, for lack of two installment payment. 3.- For voluntary resignation Article 10: Amendments 1. Any active member or officer of ISPOR Spain may propose constitutional amendments. 2. A proposed amendment to this or new Constitution should become binding after receiving a two-thirds majority of the total voting membership of ISPOR Spain. 3. Any amendments should be sent to the ISPOR office at ISPOR, 3100 Princeton Pike Building 3E, Lawrenceville, NJ, USA 08648 or email to: regionalchapter@ispor.org. Article 11: Indemnification 1. ISPOR Spain will indemnify ISPOR from liability for injury or damage, cost or expense resulting from or which arises out of or in connection with the use by ISPOR Spain of the ISPOR name, logo, or arising from the relationship or affiliation between the parties.