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What more can we do to understand the process and improve our results? REPRODUCTIVE MEDICINE AND BEYOND The 4 th International Congress SPONSORSHIP and EXHIBITION PROSPECTUS Last update: January 9, 2011 www.comtecmed.com/ivi IVI@comtecmed.com

Dear Friends and Colleagues, Following the success of our three previous IVI Congresses, we would like to invite you to our next congress to be held in Valencia, Spain, and April 7-9, 2011. Our aim is to continue providing top-level reproductive medicine congresses, addressing cutting edge topics in this continuously evolving field of human reproduction and offering the most reputable international speakers available. Valencia is located on the Mediterranean Sea and is the third largest city of Spain. It is a city of great cultural and historical importance, combining sights from its impressive past with new emblematic buildings. The "City of Arts and Sciences," the Oceanographic and the Palace of Arts are amongst the jewels of Valencia's architectural and cultural settings. The Mediterranean climate and regional food offer a wide variety of possibilities to enjoy your stay. There is no doubt that with your enthusiasm, your scientific achievements and you willingness to share your best and newest research will make the Valencia Congress a great success. See you soon Prof. Antonio Pellicer Prof. Jose Remohi (2)

COMMITTEES HONORARY PRESIDENTS Antonio Pellicer José Remohí CONGRESS PRESIDENTS Juana Crespo Amparo Ruiz EXECUTIVE DIRECTOR Antonio Requena INTERNATIONAL ADVISORY COMMITTEE Aydin Arici, USA Pedro Barri, Spain Paul Devroey, Belgium Sudhansu K. Dey, USA Marco Filicori, Italy Fanny Vidal, Spain SCIENTIFIC COMMITTEE MEMBERS Carlos Simón, Chairman María Delgado, Scientific Secretary José Bellver Gloria Calderón Juan Antonio García Velasco José Antonio Horcajadas Antonio Pellicer José Remohí Antonio Requena Carmen Rubio (3)

TIMETABLE 15:00-17:00 Session 1 OVARIAN STIMULATION UPDATE 17:00-17:30 Coffee Break 17:30-19:30 Session 2 ADVANCED MATERNAL AGE THURSDAY, APRIL 7, 2011 Hall A FRIDAY, APRIL 8, 2011 Hall B 08:30-10:30/11:00 Session 3a Session 3b THE ROLE OF THE ENDOMETRIUM METHODS FOR THE SELECTION OF AS A FERTILITY FACTOR THE MOST COMPETENT GAMETE Debate: Mild vs. Conventional ovarian stimulation 11:00-11:30 Coffee Break 10:30-11:00 Coffee Break 11:00-13:00 Session 4a Session 4b RECURRENT MISCARRIAGE INNOVATIVE STRATEGIES FOR PRE- IMPLANTATION AND PRENATAL GENETIC DIAGNOSIS 13:00-14:00 Lunch Break 14:00-16:00 Session 5 LONG-TERM CONSEQUENCES OF ASSISTED REPRODUCTION 16:00-16:30 Coffee Break 16:30-17:00 Clinical Award Ceremony 17:00-18:00 Debate: Why IVF results are better in the USA than in the EU? 18:00-18:45 Oral Presentation Abstracts Award Ceremony SATURDAY, APRIL 9, 2011 08:30-10:30 Session 6 NON-INVASIVE DIAGNOSIS IN MODERN ART 10:30-11:00 Coffee Break 11:00-11:30 Best Research Award Ceremony 11:30-13:30 Session 7 NEW TECHNOLOGIES THAT WILL IMPACT OUR CLINICAL ROUTINE (4)

PRELIMINARY SCIENTIFIC PROGRAM THURSDAY, APRIL 7, 2011 Hall A 15:00-17:00 Session 1 OVARIAN STIMULATION UPDATE 15:00-15:30 Ovarian stimulation for IVF: The optimal balance between to much and to little B. Fauser, The Netherlands 15:30-16:00 Present stimulation is the past of tomorrow P. Devroey, Belgium 16:00-16:30 ART outcome: The total number of embryos replaced as a predictor of success A. Pellicer, Spain 16:30-17:00 OHSS: Strategies for prevention Z. Rosenwaks, USA 17:00-17:30 Coffee Break 17:30-19:30 Session 2 ADVANCED MATERNAL AGE 17:30-18:00 How to predict bad prognosis patients F. Broekmans, The Netherlands 18:00-18:30 What does and does not work in AMA patients? F. Olivennes, France 18:30-19:00 New alternatives for AMA patients J.A. Garcia Velasco, Spain 19:00-19:30 Does PGS have a role? Pros and cons C. Rubio, Spain (5)

PRELIMINARY SCIENTIFIC PROGRAM FRIDAY, APRIL 8, 2011 Hall A 08:30-11:00 Session 3a THE ROLE OF THE ENDOMETRIUM AS A FERTILITY FACTOR 08:30-09:00 Intramural fibroids and infertility: An update review M. Aboulghar, Egypt 09:00-09:30 Effect of thin endometrium in ART R. Frydman, France 09:30-10:00 Importance of high progesterone levels in the follicular phase E. Bosch, Spain 10:00-11:00 Debate: Mild vs. Conventional ovarian stimulation Moderator: P. Barri, Spain Pro: B. Fauser, The Netherlands Con: R. Franchin, France 11:00-11:30 Coffee Break 11:30-13:00 Session 4a RECURRENT MISCARRIAGE 11:30-12:00 Uterine anomalies R. Campo, Belgium 12:00-12:30 Inherited thrombophilia B. Brenner, Israel 12:30-13:00 Alloinmmune factors R. Rai, UK 13:00-14:00 Lunch Break (6)

PRELIMINARY SCIENTIFIC PROGRAM FRIDAY, APRIL 8, 2011 Hall A 14:00-16:00 Session 5 LONG-TERM CONSEQUENCES OF ASSISTED REPRODUCTION 14:00-14:30 Cancer risk J. Bellver, Spain 14:30-15:00 Chromatin and RNA-based epigenetic inheritance systems B. Horsthemke, Germany 15:00-15:30 Periconceptional determinants of adult health: What should the Fertility Specialist know? N. Macklon, The Netherlands 15:30-16:00 Neuromotor, cognitive and behavioural outcome in the offspring K.J. Middelburg, The Netherlands 16:00-16:30 Coffee Break 16:30-17:00 Clinical Research Award Ceremony 17:00-18:00 Debate: What can be done to improve our ART outcome: The American and the European experience Moderator: J.A. Garcia Velasco, Spain USA: Z. Rosenwaks, USA UK: P. Devroey, Belgium 18:00-18:45 Oral Presentation Abstracts Award Ceremony (7)

PRELIMINARY SCIENTIFIC PROGRAM FRIDAY, APRIL 8, 2011 Hall B 08:30-10:30 Session 3b METHODS FOR THE SELECTION OF THE MOST COMPETENT GAMETE 08:30-09:00 The use of oxygen consumption to select the best oocyte M. Meseguer, Spain 09:00-09:30 IMSI J.F. Velez De la Calle, France 09:30-10:00 Sperm selection by molecular profiling N. Garrido, Spain 10:00-10:30 Developmental sperm contributions: Fertilization and beyond S. Oenhinger, USA 10:30-11:00 Coffee Break 11:00-13:00 Session 4b INNOVATIVE STRATEGIES FOR PRE-IMPLANTATION AND PRENATAL GENETIC DIAGNOSIS 11:00-11:30 Use of comprehensive chromosomal screening for embryo assessment D. Wells, UK 11:30-12:00 Genomics of cumulus cells S. Hamamah, France 12:00-12:30 Cancer predisposition and PGD J. Martin, Spain 12:30-13:00 Use of cell-free nucleic acids in maternal blood for non-invasive prenatal diagnosis TBA 13:00-14:00 Lunch Break (8)

PRELIMINARY SCIENTIFIC PROGRAM SATURDAY, APRIL 9, 2011 Hall A 08:30-10:30 Session 6 NON-INVASIVE DIAGNOSIS IN MODERN ART 08:30-09:00 Identification of viable embryos by non-invasive measurement of amino acids H. Leese, Israel 09:00-09:30 Aneuploidy detection by metabolomic profiling F. Domingeuz, Spain 09:30-10:00 Secretomics of endometrial fluid for non-invasive assessment of endometrial receptivity N. Macklon, The Netherlands 10:00-10:30 Lipodomics as a non-disruptive diagnosis tool of endometrial receptivity O. Berlanga, Spain 10:30-11:00 Coffee Break 11:00-11:30 Basic Research Award Ceremony 11:30-13:30 Session 7 NEW TECHNOLOGIES THAT WILL IMPACT OUR CLINICAL ROUTINE 11:30-12:00 Massive sequencing and its application in human reproduction D. Ramón Vidal, Spain 12:00-12:30 Epigenetic mechanisms: Possible implications in reproductive biology M. Esteller, Spain 12:30-13:00 Generation of artificial gametes: Are we close? R. Reijo, USA 13:00-13:30 Endometrial stem cells and its translation C. Simon, Spain (9)

CATEGORIES OF SPONSORSHIP The following are the sponsorship levels according to the total amount of sponsorship, which includes Symposia, Sponsorship Items and Exhibition. PRESIDENTIAL CIRCLE 100,000 and up PLATINUM 80,000-100,000 GOLD 50,000-80,000 SILVER 20,000-50,000 SPONSOR 2,000-20,000 Exhibitors who contribute minimum 3,600 will be acknowledged as Exhibitors. DEADLINE FOR CHOICE OF SPONSORSHIP OPTIONS Presidential circle and Platinum November 1, 2010 Gold and Silver December 15, 2010 (10)

MAJOR SPONSORSHIP CATEGORIES PRESIDENTIAL CIRCLE SPONSORSHIP PACKAGE 100,000 + (limited to two companies) The Sponsor may provide an unrestricted grant to support an existing plenary session CME-approved session (1.5-2 hours) as part of the Scientific Program. PROVIDED BY THE CONGRESS Plenary Educational session Exclusive sponsorship of an official plenary session Rental of session hall, standard audiovisual equipment and display table Registration 50 congress registrations A 100-word sponsor/product profile will be published in the final Congress Program Exhibition Exhibition space of 50 sq.m (Additional space may be purchased at the reduced price of 350 per sq.m) 6 registrations for exhibitors (Additional exhibitors registrations may be purchased at 250 per person) Additional item Priority in choosing up two additional sponsorship items up to a total value of 20,000 Advertisements & Acknowledgment Two A4 advertisements, full color, will be included in the final Congress Program The Sponsor's logo will be published on the Congress Website The Sponsor's brochure will be inserted in the participants' bags (11)

MAJOR SPONSORSHIP CATEGORIES PLATINUM SPONSORSHIP PACKAGE 80,000 + (limited to two companies) The Sponsor may provide an unrestricted grant to support an existing plenary session CME-approved session (1.5-2 hours) as part of the Scientific Program. The expenses of the chairpersons and speakers of the session (registration, accommodation and travel) will be the responsibility of the Sponsor. PROVIDED BY THE CONGRESS Parallel Educational session Exclusive sponsorship of an official CME approved session Rental of session hall, standard audiovisual equipment and display table. Registration 30 congress registrations A 100-word sponsor/product profile will be published in the final Congress Program Exhibition Exhibition space of approximately 24 sq.m (Additional space may be purchased at the reduced price of 350 per sq.m ) 4 registrations for exhibitors (Additional exhibitors registrations may be purchased at 250 per person) Additional item Priority in choosing up two additional sponsorship items up to a total value of 15,000 Advertisements & Acknowledgment Two A4 advertisements, full color, will be included in the final Congress Program The Sponsor's logo will be published on the Congress Website The Sponsor's brochure will be inserted in the participants' bags (12)

MAJOR SPONSORSHIP CATEGORIES GOLD SPONSORSHIP PACKAGE 50,000 + (limited to four companies) The Sponsor may provide an unrestricted grant to support an existing plenary session CME-approved session (1.5-2 hours) as part of the Scientific Program. The expenses of the chairpersons and speakers of the session (registration, accommodation and travel) will be the responsibility of the Sponsor. PROVIDED BY THE CONGRESS Plenary Educational session Exclusive sponsorship of an official CME approved session Rental of session hall, standard audiovisual equipment and display table. Registration 15 congress registrations A 100-word sponsor/product profile will be published in the final Congress Program Exhibition Exhibition space of approximately 18 sq.m (Additional space may be purchased at the reduced price of 350 per sq.m ) 4 registrations for exhibitors (Additional exhibitors registrations may be purchased at 350 per person) Additional item Priority in choosing up two additional sponsorship items up to a total value of 10,000 Advertisements & Acknowledgment One A4 advertisement, full color, will be included in the final Congress Program The Sponsor's logo will be published on the Congress Website The Sponsor's brochure will be inserted in the participants' bags (13)

MAJOR SPONSORSHIP CATEGORIES SILVER SPONSORSHIP PACKAGE 20,000 (limited to six companies) The Sponsor may provide an unrestricted grant to support an existing plenary session CME-approved session (1.5-2 hours) as part of the Scientific Program. The expenses of the chairpersons and speakers of the session (registration, accommodation and travel) will be the responsibility of the Sponsor. PROVIDED BY THE CONGRESS Plenary Educational session Exclusive sponsorship of an official CME approved session Rental of session hall, standard audiovisual equipment and display table. Registration 4 congress registrations A 100-word sponsor/product profile will be published in the final Congress Program Exhibition Exhibition space of 12 sq.m (Additional space may be purchased at the reduced price of 350 per sq.m ) 4 registrations for exhibitors (Additional exhibitors registrations may be purchased at 350 per person) Advertisements & Acknowledgment One A4 advertisement, full color, will be included in the final Congress Program The Sponsor's logo will be published on the Congress Website The Sponsor's brochure will be inserted in the participants' bags (14)

SPONSORSHIP OPPORTUNITIES In addition to the major sponsorship categories, a range of other sponsorship opportunities is available to meet various needs. LUNCH SOLE SPONSORSHIP 20,000 (per lunch) The Sponsor may subsidize a buffet lunch served on Friday, April 8, 2011. Lunch will be served at the exhibition area. Five complimentary registrations (for the Sponsor s representatives) The Sponsor's logo will appear on a special board at the lunch venue A 100-word sponsor/product profile will be published in the final Congress Program One A4 advertisement, full color, will be published in the final Congress Program The Sponsor's logo will be published on the Congress Website, providing a two-way link The Sponsor s brochure will be inserted in the participants' bags WELCOME RECEPTION SOLE SPONSORSHIP 15,000 A Welcome Reception for all participants will be held on Thursday evening. The Sponsor s logo will appear on a special board at the Welcome Reception venue A 100-word sponsor/product profile will be published in the final Congress Program One A4 advertisement, full color, will be published in the final Congress Program The Sponsor s logo will be published on the Congress Website, providing a two-way link The Sponsor s brochure will be inserted in the participants' bags (15)

SPONSORSHIP OPPORTUNITIES CONGRESS PROGRAM SOLE SPONSORSHIP SOLD (This opportunity is reserved for Platinum and Gold sponsors on a first-come-first served basis) The final Congress Program will include the Scientific Program and the Scientific Abstracts of the Congress. The Congress Program will be distributed to all participants and will be an invaluable reference book after the Congress. One A4 advertisement, full color, will be published on the back cover of the final Congress Program A 150-word sponsor/product profile will be published in the final Congress Program The Sponsor's logo will be published on the Congress Website providing a two-way link FACULTY DINNER SOLE SPONSORSHIP 10,000 A Faculty Dinner will be held for the invited speakers of the Congress. The Sponsor s logo will appear on a special board at the Faculty Dinner venue The Sponsor s logo will be published on the Congress Website PARTICIPANTS BAGS SOLE SPONSORSHIP SOLD (This opportunity is reserved for Platinum and Gold sponsors on a first-come-first served basis) The Sponsor will provide the participants Congress bags. The Sponsor's brochure/s will be inserted in the participants' bags The Sponsor's logo will be published on the Congress Website, providing a two-way link The Sponsor s logo will appear on a Special Board on site (16)

SPONSORSHIP OPPORTUNITIES INTERNET CENTER SOLE SPONSORSHIP SOLD (This opportunity is reserved for Platinum and Gold sponsors on a first-come-first served basis) The Internet Center will be outfitted with internet workstations for participants of the Congress to check their email and stay updated in-between sessions. The sponsorship package includes: workstations, areas for corporate logo display, technical support, adequate space for the workstations and internet set-up and connection. the opportunity to Display Sponsor logo/information on screensaver Display Sponsor logo/information on screen background Distribute mouse pads and related promotional gifts at the internet center The Sponsor s logo will be published on the Congress Website, providing a two-way link The Sponsor will be acknowledged in the final Congress Program and the logo will appear on a separate Sponsor Logo page CONGRESS ABSTRACTS ON USB STICK SOLE SPONSORSHIP SOLD The USB stick will contain all of the Scientific Abstracts of the Congress and will be distributed to all the participants. The USB stick may include the Sponsor s logo. An exchange voucher will be placed in the participants registrations kit. The USB stick will be distributed from the sponsor's exhibition booth (optional). Exclusive advertisement on the cover of the exchange voucher Sponsor's logo on the USB stick The Sponsor s logo will appear on a Special Board on site and on the official Congress Web Site. MINI/POCKET PROGRAM SOLE SPONSORSHIP SOLD A Mini/Pocket Program will be distributed to all participants with their registration kits. The Sponsor s exclusive advertisement on the back cover of the Mini/Pocket Program The Sponsor's logo will be published on the Congress Website, providing a two-way link (17)

SPONSORSHIP OPPORTUNITIES WRITING PADS AND PENS SOLE SPONSORSHIP provided-in-kind + 5,000 The Sponsor will provide all participants with writing pads and pens, which will be included in the participants bags. This can be an effective high-profile sponsorship opportunity for a drug launch or for immediate brand recognition. The Sponsor s logo will be published on the Congress Website, providing a two-way link The writing pads and pens will bear the Sponsor s company product/logo CONGRESS LANYARDS SOLE SPONSORSHIP The Sponsor provides printed lanyards for the name badges The Congress provides printed lanyards for the name badges (This opportunity is reserved for Platinum and Gold sponsors on a first-come-first served basis) The Sponsor/product name, logo or text printed on lanyards The Sponsor s logo will be published on the Congress Website, providing a two-way link The Sponsor s logo will appear on a Special Board on site TRANSLATION 5,000 (per hall, per day) BROCHURE INSERTS 3,000 3,000 6,000 Simultaneous translation from English to any required language. The Sponsor s logo will appear on a special board in the session hall The Sponsor's logo will be published on the Congress Website The Sponsor will be acknowledged in the final Congress Program, and the Sponsor s logo A brochure provided by the Sponsor will be inserted into the participants bags, which will be distributed to the participants of the Congress. The Sponsor s logo will be published on the Congress Website, providing a two-way link (18)

SPONSORSHIP OPPORTUNITIES EUROPEAN SPEAKER 3,000 The Sponsor may support in part the expenses of one or more invited European Speakers. Expenses include registration, accommodation and travel. The Sponsor s logo will be published on the Congress Website, providing a two-way link An A4 advertisement, full color, will be published in the final Congress Program NON-EUROPEAN SPEAKER 6,000 The Sponsor may support in part the expenses of one or more invited Non-European Speakers. Expenses include registration, accommodation and travel. The Sponsor s logo will be published on the Congress Website, providing a two-way link An A4 advertisement, full color, will be published in the final Congress Program The Sponsor s brochure will be inserted in the participants' bags COFFEE BREAK 3,000 (per coffee break) Coffee will be served during the breaks between the sessions on each day of the Congress. The Sponsor s logo will be published on the Congress Website, providing a two-way link All sponsorship and exhibition prices are subject to VAT. (19)

EXHIBITION A professional exhibition will be held at the Valencia Congress Center, in conjunction with the Congress. The floor plan has been designed so as to maximize the exhibitors exposure to the delegates. Coffee breaks and lunch will be held in this exhibition area daily, and lunch will be served on Friday, April 8, 2011. SPACE/BOOTH RENTAL Non Sponsor booth 600 per sq.m, minimum booth rental is 6 sq.m (2 x 3 sq.m) Sponsors may purchase an additional exhibition space at 350 per sq.m PROVIDED BY THE CONGRESS FOR REGISTERED EXHIBITORS Exhibitor s Technical Manual Complementary exhibitor registrations according to exhibition package Additional exhibitor registrations may be purchased at 250 per registration Invitation to Welcome Reception Lunch on Friday A 100-word sponsor/product profile will be published in the final Congress Program Cleaning of public areas ALLOCATION OF EXHIBITION BOOTH Space/booth allocation will be confirmed on a first-come first-served basis. Priority will be given to Presidential Circle and Platinum Sponsors. Please view the exhibition plan on the Congress website: www.comtecmed.com/ivi SITE INSPECTION Sponsors are welcome to visit the Congress venue. For further information, please contact our office at: ivi@comtecmed.com OCCUPATION OF SPACE/BOOTH If an exhibitor fails to occupy the allocated space before the exhibition is due to be opened to the public, or if prior to the opening it is evident that the exhibitor will not be taking up the reserved space, the Congress Organizer may make this booth available to other exhibitors without further notice. Consequently, the exhibitor will not be entitled to compensation. TERMS AND CONDITIONS Terms and conditions as well as payment and cancellation policy will be detailed in the Exhibition Agreement. (20)

GENERAL INFORMATION LOCATION Palacio de Congresos de Valencia Avda. Cortes Valencianas, 60-46015 Valencia, Spain Telephone: +34 96 317 94 00 Fax: +34 96 317 94 01 www.palcongres-vlc.com DATES Thursday, April 7-9, 2011 LANGUAGE English is the official language of the Congress CME ACCREDITATION Serono Symposia International Foundation will submit the scientific program of the reproductive medicine and beyond congress for CME accreditation. CME points will be obtained through the SSIF. LIABILITY The Congress & Administrative Secretariat cannot accept liability for personal accidents, nor for loss of, or damage to private property of participants, either during or directly arising from the Reproductive Medicine and Beyond Congress. Participants should make their own arrangements with respect to health and travel insurance. SECRETARIAT Scientific Secretariat: IVI - VALENCIA Tel: +34 96-3050978 Email: mdelgado@ivi.es Sponsorship and Exhibition Contact ComtecMed 53, Rothschild Boulevard, P.O Box 68 Tel Aviv, 61000, Israel Tel: +972 3 5666166 Fax: +972 3 5666177 Website: www.comtecmed.com/ivi Email: ivi@comtecmed.com (21)

What more can we do to understand the process and improve our results? REPRODUCTIVE MEDICINE AND BEYOND The 4 th International Congress IVI - Comtec International M E D I C A L C O N G R E S S E S Headquarters and Administration: 53 Rothschild Boulevard, PO Box 68, Tel Aviv 61000, Israel Tel: +972-3-5666166 Fax: +972-3-5666177 Email: info@comtecmed.com Comtec Spain: Bailén, 95-97, pral. 1. a - 08009 Barcelona, Spain Tel: +34-93-2081145 Fax: +34-93-4579291 Email: spain@comtecmed.com Comtec China: 175 Xiang Yang Road South, Shanghai 200031, China Tel: +86-21-54660460 Fax: +86-21-54660450 Email: china@comtecmed.com www.comtecmed.com/ivi IVI@comtecmed.com