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THE ACADEMY FOR CLINICAL DEBATES & CONTROVERSIES IN MEDICINE The 2 nd International Congress on CONTROVERSIES IN STEM CELL TRANSPLANTATION AND CELLULAR THERAPIES Last update: November 14, 2012 BERLIN GERMANY October 10-13, 2013 SPONSORSHIP & EXHIBITION PROSPECTUS 23 www.comtecmed.com/costem

Dear Friends and Colleagues, Following the success of the 1 st International Congress on Controversies in Stem Cell and Cellular Therapies (COSTEM), we are honored to invite you to the 2 nd COSTEM Congress to be held in Berlin, Germany on October 10-13, 2013. The 2 nd COSTEM Congress is a progressive, compelling and informative Congress. COSTEM will act as a unique platform where the most compelling and controversial topics facing clinicians in these fields are presented in an enticing and exciting debate forum. The Congress promotes excellence through dynamic debate forums and international expert presentations. Aiming to integrate expanses of information with its implementation in best clinical care, this state-of-the-art Congress is unique in its focus to resolving vital controversies in Stem Cell and Cellular Therapies. COSTEM provides international experts and clinicians with an opportunity to share, express and compare experiences to establish reliable treatments for patients. This interactive Congress encourages the audience to actively participate in debate discussions and challenges world experts to debate their stance on a range of burning issues. We invite you to participate in this innovative Congress in 2013. Join us in Berlin! Prof. N. Kröger and Prof. A. Nagler Co-Chairpersons On behalf of the Organizing Committee

CONGRESS PROFILE Aims of the Congress To promote excellence in the field of Stem Cell Transplantation and Cellular Therapies, by discussing, in a debate forum, evidence-based medicine and expert opinions on current controversial issues To bridge gaps between expansion of basic science and information, and their consolidation into clinical practice To promulgate ethics and standards of practice and treatment To reach consensus on certain controversial issues, through debates, round table discussions and plenary lectures To make it possible for the industry to meet with outstanding experts in the field, and to update international participants on pressing clinical and technological questions of the day PAST CONGRESS AND STATISTICS COSTEM 2011 Berlin, Germany September 8-11, 2011 Sessions 21 Debates 38 Faculty 78 Poster Abstracts 36 demographics 3

Co-Chairpersons Prof. N. Kröger, Germany Prof. A. Nagler, Israel Organizing committee Jürgen Finke, Germany Alejandro Madrigal, UK Dietger Niederwieser, Germany Jacob M. Rowe, Israel Local Organizing Committee Renate Arnold, Germany Lutz Uharek, Germany 4

Preliminary List of Topics Preliminary Topics SCT in Myeloma and MDS Relapse prevention Treatment and Prevention of Relapse AML and CML Lymphoma GvHD Prevention by Antibodies Cell and Gene Therapy Improving Transplant Outcome in Multiple Myeloma ALL and Intensity of Conditioning Regimen Refractory and Residual Leukemia GvHD Prevention by T-Cell Modulation Aplastic Anemia and Autoimmune Diseases Donor Selection Fungal Resistance T-Cell Depletion and Mesenchymal Stroma Cells Myelofibrosis and Haploidentical Transplantation Allogeneic SCT for Myeloma and Hodgkin s Disease Infection Preliminary Debates Autologous SCT as first line treatment? Allo SCT in elderly patients (>60 y) with MDS Aspergillus resistance is only seen on the petri dish and not in the patient Can we prevent relapse by novel conditioning regimen? Relapse prevention: Prophylactic DLI? Should CMV infection post allo SCT be treated by cellbased therapy? Is double cord blood to be preferred to a single unit? Autologous SCT for autoimmune disease Should cord blood unit be selected according to HLA or cell-based? Should we expand cord blood? Transplantation for T-cell lymphoma Should all MRD positive patients receive allo SCT? Is photopheresis treatment of choice for cgvhd? Is there a place for allo SCT in Hodgkin s disease? Is it possible to separate GvHD from GvL? MSC for GvHD Reduced or standard conditioning? Second allo for relapse Donor selection to prevent relapse Indication for unrelated allo SCT in 1. CR AML Is there any place for the prophylactic collection of autologous stem cells for major radiation incidents? GvHD prevention Is combined antifungal therapy more efficient than single agent therapy? MUD or immunsuppressive therapy for aplastic anemia Therapy post transplantation in MM Which is the donor of choice if no MUD is available? Autologous SCT in FL Allo SCT for refractory leukemia Can Treg prevent GvHD without losing GvL? Is there a place for allo SCT in treatment of MM? Allogeneic SCT for CML after failure to 1. TKI T-cell depletion and T-cell add back Should CR be target of therapy in MM? Is there a role for allo SCT in standard risk ALL? 23 5

CATEGORIES OF SPONSORSHIP Presidential Circle 75,000 and up Platinum 50,000-75,000 GOLD 25,000-50,000 SILVER 10,000-25,000 Sponsor 2,000-10,000 6

Scientific sponsorship OpportunitIES Continuing medical education (CME) Approved SESSION 30,000 An unrestricted grant to support an existing session, or to suggest a CME-approved session (60-90 minutes) as part of the Scientific Program. Educational Session Session hall and basic audiovisual equipment Four complimentary registrations for Session Chairpersons and Speakers Exhibition 6 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) Advertisement Package One full page color advertisement in the Congress Program Book Brochure in the participants bags Promotion Optional webcast of Session at discounted rates Company logo on regular announcements to Congress Database The expenses (travel, accommodation and registration) of the Chairpersons and Speakers of a supported CMEapproved session are additional and the responsibility of the Sponsor. 23 8

Scientific sponsorship OpportunitIES industrial Symposium (NON-CME APPROVED) 40,000 An industrial non-cme approved symposium (60-90 minutes) as part of the Scientific Program. The content and Speakers will be subject to approval by the Organizing Committee. Educational Session Symposium hall and basic audiovisual equipment Five complimentary registrations for Symposium Chairpersons and Speakers Exhibition 12 sq.m exhibition space (additional space available at reduced rates) Two exhibitor registrations (additional registrations available at reduced rates) Advertisement Package One full page color advertisement in the Congress Program Book Brochure in the participants bags Promotion Optional webcast of Symposium at discounted rates Company logo on regular announcements to Congress Database Specially-designed mailshots announcing Industrial Symposium to Sponsor s subsidiaries and affiliates The expenses (travel, accommodation and registration) of the Chairpersons and Speakers of a sponsored Industrial Symposium are additional and the responsibility of the Sponsor. EUROPEAN SPEAKER 3,000 An unrestricted grant to cover, in part, the expenses of one invited European Speaker. Expenses include travel, accommodation and registration. One full page color advertisement in the Congress Program Book 8

Scientific sponsorship OpportunitIES NON-EUROPEAN SPEAKER 6,000 An unrestricted grant to cover, in part, the expenses of one invited non-european Speaker. Expenses include travel, accommodation and registration. One full page color advertisement in the Congress Program Book PRIZES FOR OUTSTANDING ABSTRACTS 4,000 Prizes will be awarded to the authors of the most outstanding abstracts/posters, as chosen by the Congress Chairpersons. Company representatives will be invited to attend the Award Ceremony 23

sponsorship OpportunitIES LUNCH 25,000 (per lunch) Opportunity to subsidize, in part, a buffet lunch to be served to all participants of the Congress. Two complimentary registrations One full page color advertisement in the Congress Program Book Brochure in the participants bags WELCOME RECEPTION 10,000 A Welcome Reception for all participants will be held on Thursday evening. Two complimentary registrations Company logo on the official invitation Acknowledgment on special board on-site during the Welcome Reception One full page color advertisement in the Congress Program Book Brochure in the participants bags FACULTY DINNER 10,000 A dinner will be held for the invited Speakers of the Congress. Two complimentary registrations Company logo on the official invitation One full page color advertisement in the Congress Program Book Brochure in the participants bags 10

sponsorship OpportunitIES CONGRESS PROGRAM BOOK 10,000 The Congress Program Book will include the Scientific Program and the Scientific Abstracts, and will be distributed to all participants. Full page color advertisement on the back cover of the Congress Program Book Additional full page color advertisement in the Congress Program Book INTERNET CENTER 10,000 The Internet Center will be outfitted with internet workstations for participants of the Congress to stay updated between sessions. The Sponsor may: Display logo as a screensaver Display logo on screen background PARTICIPANTS BAGS provided-in-kind + 10,000 The opportunity to provide branded bags for all participants of the Congress. Brochure in the participants bags 23 11

sponsorship OpportunitIES CONGRESS ABSTRACTS ON THE WEBSITE 8,000 The Scientific Abstracts of the Congress will be placed on the Congress Website and will be available for a limited period. POCKET PROGRAM 5,000 A Pocket Program will be distributed to all participants in their Congress Kits. Exclusive advertisement on the back cover of the Pocket Program Brochure in the participants bags TRANSLATION 5,000 (per hall, per day) Simultaneous translation into any required language. WRITING PADS AND PENS provided-in-kind + 5,000 The opportunity to provide branded writing pads and pens that will be included in the participants bags. 12

sponsorship OpportunitIES CONGRESS LANYARDS The Sponsor will provide printed lanyards for the name badges 5,000 The Congress will provide printed lanyards for the name badges 8,000 This sponsorship opportunity is reserved for Presidential Circle, Platinum and Gold Sponsors, and will be available on a first-come, first-served basis. BROCHURE INSERT 3,000 Company brochure to be inserted into the participants bags, which will be distributed at the Congress. COFFEE BREAK 3,000 (per coffee break) There will be daily coffee breaks between sessions throughout the Congress. TAILOR-MADE SPONSORSHIP PACKAGES Sponsorship packages may be tailored to suit the Sponsor s marketing strategy in order to maximize visibility, and to best promote products and services. Please contact the Congress Organizer for further details on creating the appropriate package. 23 13

EXHIBITION An exhibition will be held in conjunction with the Congress. The exhibition floorplan is designed to maximize exposure to the participants. All lunches and coffee breaks will be held in the exhibition area. Exhibition space will be available on a first-come, first-served basis, with priority given to Presidential Circle, Platinum and Gold Sponsors. Exhibition space will be available at 500 per sq.m. The minimum booth size is 2x3 sq.m. Please visit www.comtecmed.com/costem to view the exhibition floorplan. Exhibition space rental is priced according to size (per sq.m) and includes: Net stand area Company profile in Congress Program Book Two exhibitor registrations Exhibitors Manual General cleaning of public areas Venue security Stand equipment and additional services may be ordered by means of the forms in the Exhibitors Manual: Furniture, partition walls, carpets, telephone and data lines, electricity, stand cleaning, exhibitors insurance, logistics, etc.

General Information Language The official language of the Congress is English. Registration Early Registration Late Registration From Oct 2, 2013 Until from August 6 until and On Site August 5, 2013 Oct 1, 2013 Participants - 490 540 590 Physicians and Scientists Residents, Nurses, Students 365 410 450 Registration fees include: Participation in scientific sessions, Congress bag, program and abstract book, all printed material of the Congress, invitation to the Welcome Reception, coffee breaks, lunch on Friday and Saturday. Terms and Conditions: All sponsorship and exhibition prices quoted are in and are subject to VAT Time slot allocation will be based on level of sponsorship and approval from the Scientific Committee It is the responsibility of the Sponsors and Exhibitors to comply with the regulations of the local authorities, EFPIA (European Federation of Pharmaceutical Industries & Associations) www.efpia.org and IFMPA (International Federation of Pharmaceutical Manufacturers & Associations) www.ifpma.org Code of Practice on the Promotion of Medicines. The Congress Organizer reserves the right to accept or decline offers of sponsorship and application for exhibition space The Congress Organizer reserves the right to amend the published floorplan should it be deemed necessary for the benefit the exhibition and the Congress as a whole Please note that the Congress Organizer must approve all exhibition stand designs Congress Organizer and Sponsorship / Exhibition Contact: 53, Rothschild Boulevard, PO Box 68 Tel Aviv, 6100001, Israel Tel: +972 3 5666166 Fax: +972 3 5666177 E-mail: costem@comtecmed.com Website: www.comtecmed.com/costem Liability and Insurance The organizer carries no liability whatsoever for injuries or damages involving persons and/or property during the Congress. Participants are advised to issue their own personal travel and health insurance for their trip. 23 15

THE ACADEMY FOR CLINICAL DEBATES & CONTROVERSIES IN MEDICINE The 2 nd International Congress on CONTROVERSIES IN STEM CELL TRANSPLANTATION AND CELLULAR THERAPIES BERLIN GERMANY October 10-13, 2013 www.comtecmed.com/costem