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UITED STATES DISTRICT COURT, WESTER DISTRICT OF WASHIGTO AT SEATTLE I RE ORTHWEST BIOTHERAPEUTICS IC. SECURITIES LITIGATIO THIS DOCUMET RELATES TO: Master o. C07-1254-RAJ CLASS ACTIO ALL ACTIOS PROOF OF CLAIM AD RELEASE I. GEERAL ISTRUCTIOS 1. To recover as a member of the class based on your claims in the action entitled In re orthwest Biotherapeutics, Inc. Securities Litigation, o. C-07-1254-RAJ (the Litigation ), you must complete and, on page 7 hereof, sign this Claim and Release. If you fail to file a properly addressed (as set forth in paragraph 3 below) Claim and Release, your claim may be rejected and you may be precluded from any recovery from the et Settlement Fund created in connection with the proposed settlement of the Litigation. 2. Submission of this Claim and Release, however, does not assure that you will share in the proceeds of settlement in the Litigation. 3. OU MUST MAIL OUR COMPLETED AD SIGED PROOF OF CLAIM AD RELEASE POSTMARKED O OR BEFORE JUL 16, 2009, ADDRESSED AS FOLLOWS: orthwest Biotherapeutics Securities Litigation c/o Gilardi & Co. LLC Claims Administrator P.O. Box 8040 San Rafael, CA 94912-8040 1-866-780-8824 If you are OT a Member of the Class, as defined in the otice of Pendency and Proposed Settlement of Class Action ( otice ), DO OT submit a Claim and Release form. 4. If you are a Member of the Class, you are bound by the terms of any judgment entered in the Litigation, WHETHER OR OT OU SUBMIT A PROOF OF CLAIM AD RELEASE FORM. II. DEFIITIOS 1. Defendants means orthwest Biotherapeutics, Inc., Toucan Capital Fund II, L.P., Toucan Partners LLC and the Individual Defendants. 2. Individual Defendants means Linda Powers and Alton Boynton. 3. Released Persons means each and all of the Defendants and each and all of their Related Parties. III. CLAIMAT IDETIFICATIO 1. If you purchased the publicly-traded common stock of orthwest Biotherapeutics on the US and/or London markets and held the certificate(s) in your name, you are the beneficial purchaser as well as the record purchaser. If, however, the certificate(s) were registered in the name of a third party, such as a nominee or brokerage firm, you are the beneficial purchaser and the third party is the record purchaser. 2. Use Part I of this form entitled Claimant Identification to identify each purchaser of record ( nominee ), if different from the beneficial purchaser of orthwest Biotherapeutics common stock which form the basis of this claim. THIS CLAIM MUST BE FILED B THE ACTUAL BEEFICIAL PURCHASER OR PURCHASERS, OR THE LEGAL REPRESETATIVE OF SUCH PURCHASER OR PURCHASERS OF THE ORTHWEST BIOTHERAPEUTICS COMMO STOCK UPO WHICH THIS CLAIM IS BASED. *WBT1FIRST* 1

3. All joint purchasers must sign this claim. Executors, administrators, guardians, conservators and trustees must complete and sign this claim on behalf of Persons represented by them and their authority must accompany this claim and their titles or capacities must be stated. The Social Security (or taxpayer identification) number and telephone number of the beneficial owner may be used in verifying the claim. Failure to provide the foregoing information could delay verification of your claim or result in rejection of the claim. IV. CLAIM FORM 1. Use Part II of this form entitled Schedule of Transactions in orthwest Biotherapeutics Publicly-Traded Common Stock to supply all required details of your transaction(s) in orthwest Biotherapeutics common stock. If you need more space or additional schedules, attach separate sheets giving all of the required information in substantially the same form. Sign and print or type your name on each additional sheet. 2. On the schedules, provide all of the requested information with respect to all of your purchases and all of your sales of orthwest Biotherapeutics publicly-traded common stock on the US and/or London markets which took place at any time between April 17, 2007 and October 15, 2007 (the Class Period ), whether such transactions resulted in a profit or a loss. Failure to report all such transactions may result in the rejection of your claim. 3. List each transaction in the Class Period separately and in chronological order, by trade date, beginning with the earliest. ou must accurately provide the month, day and year of each transaction you list. 4. Broker confirmations or other documentation of your transactions in orthwest Biotherapeutics common stock should be attached to your claim. Failure to provide this documentation could delay verification of your claim or result in rejection of your claim. 5. The above requests are designed to provide the minimum amount of information necessary to process the simplest claims. The Claims Administrator may request additional information as required to efficiently and reliably calculate your losses. In some cases where the Claims Administrator cannot perform the calculation accurately or at a reasonable cost to the Class with the information provided, the Claims Administrator may condition acceptance of the claim upon the production of additional information and/or the hiring of an accounting expert at the Claimant s cost. 6. OTICE REGARDIG ELECTROIC FILES: Certain claimants with large numbers of transactions may request, or may be requested, to submit information regarding their transactions in electronic files. All claimants MUST submit a manually signed paper Claim form whether or not they also submit electronic copies. If you wish to file your claim electronically, you must contact the Claims Administrator at 1-866-780-8824 or visit their website at www.gilardi.com to obtain the required file layout. o electronic files will be considered to have been properly submitted unless the Claims Administrator issues to the claimant a written acknowledgment of receipt and acceptance of electronically submitted data. *WBT1SECOD* 2

Official Office Use Only UITED STATES DISTRICT COURT WESTER DISTRICT OF WASHIGTO In re orthwest Biotherapeutics, Inc. Securities Litigation o. C-07-1254-RAJ PROOF OF CLAIM AD RELEASE Please Type or Print in the Boxes Below Do OT use Red Ink, Pencil, or Staples Must be Postmarked o Later Than July 16, 2009 WBT1 PART I: CLAIMAT IDETIFICATIO Last ame (Beneficial Owner) First ame (Beneficial Owner) Last ame (Co-Beneficial Owner) First ame (Co-Beneficial Owner) IRA Trust Joint Tenancy UTMA/UGMA Individual Other Company ame (Beneficial Owner - If Claimant is not an Individual) or Custodian ame if an IRA (specify) Trustee/Asset Manager/ominee/Record Owner s ame (if Different from Beneficial Owner Listed Above) Account#/Fund# (ot ecessary for Individual Filers) Date of Trust Social Security umber Telephone umber (Work) or Taxpayer Identification umber Telephone umber (Home) Email Address Address MAILIG IFORMATIO Address City State Zip Code Foreign Province Foreign Zip Code Foreign Country ame/abbreviation FOR CLAIMS PROCESSIG OL PB PC *WBT1THIRD* D IHI S TI 3 ICI OTHER OPT MRG BOTH EMP DC L1 L2

PART II. SCHEDULE OF TRASACTIOS I ORTHWEST BIOTHERAPEUTICS PUBLICL-TRADED U.S. COMMO STOCK A. umber of shares of orthwest Biotherapeutics publicly-traded common stock held at the close of trading on April 16, 2007: Holding B. Purchases of orthwest Biotherapeutics publicly-traded common stock (April 17, 2007 and July 18, 2007, inclusive): PURCHASES Trade Date(s) of Shares (List Chronologically) umber of Common Stock Purchased Total Purchase Price Purchase M M D D 1. $ 2. $ 3. $ 4. $ 5. $ IMPORTAT: (i) If you received shares through an acquisition or merger, please identify the company acquired: (ii) Identify by number listed above all purchases in which you covered a short sale : C. Sales of orthwest Biotherapeutics publicly-traded common stock (April 17, 2007 and October 15, 2007, inclusive): SALES Trade Date(s) of Shares (List Chronologically) umber of Common Stock Sold Total Sales Price Sales M M D D 1. $ 2. $ 3. $ 4. $ 5. $ D. umber of shares of orthwest Biotherapeutics publicly-traded common stock held at the close of trading on October 15, 2007: If you require additional space, attach extra schedules in the same format as above. Sign and print your name on each additional page. OU MUST READ AD SIG THE RELEASE O PAGE 7. FAILURE TO SIG THE RELEASE MA RESULT I A DELA I PROCESSIG OR THE REJECTIO OF OUR CLAIM. Holding *WBT1FOURTH* 4

PART II. SCHEDULE OF TRASACTIOS I ORTHWEST BIOTHERAPEUTICS PUBLICL-TRADED LODO MARKETS COMMO STOCK *TPE OF CURREC B: Pounds C: Euros E. umber of shares of orthwest Biotherapeutics publiclytraded common stock held at the close of trading on April 16, 2007: *Type of Currency Holding F. Purchases of orthwest Biotherapeutics publicly-traded common stock (April 17, 2007 and July 18, 2007, inclusive): PURCHASES Trade Date(s) of Shares (List Chronologically) umber of Common Stock Purchased *Type of Currency Total Purchase Price Purchase 1. 2. 3. 4. 5. M M D D G. Sales of orthwest Biotherapeutics publicly-traded common stock (April 17, 2007 and October 15, 2007, inclusive): SALES Trade Date(s) of Shares (List Chronologically) umber of Common Stock Sold *Type of Currency Total Sales Price Sales 1. 2. 3. 4. 5. M M D D H. umber of shares of orthwest Biotherapeutics publiclytraded common stock held at the close of trading on October 15, 2007: If you require additional space, attach extra schedules in the same format as above. Sign and print your name on each additional page. OU MUST READ AD SIG THE RELEASE O PAGE 7. FAILURE TO SIG THE RELEASE MA RESULT I A DELA I PROCESSIG OR THE REJECTIO OF OUR CLAIM. *WBT1FIFTH* 5 *Type of Currency Holding

V. SUBMISSIO TO JURISDICTIO OF COURT AD ACKOWLEDGMETS I, submit this Claim and Release under the terms of the Stipulation of Settlement dated as of December 31, 2008 ( Stipulation ) described in the otice. I also submit to the jurisdiction of the United States District Court for the Western District of Washington, with respect to my claim as a Class Member (as defined in the otice) and for purposes of enforcing the release set forth herein. I further acknowledge that I am bound by and subject to the terms of any judgment that may be entered in the Litigation. I agree to furnish additional information to Lead Counsel to support this claim if required to do so. I have not submitted any other claim covering the same purchases or sales of orthwest Biotherapeutics common stock during the Class Period and know of no other Person having done so on my behalf. VI. RELEASE 1. I hereby acknowledge full and complete satisfaction of, and do hereby fully, finally and forever settle, release, relinquish and discharge, all of the Released Claims against each and all of the Defendants and each and all of their Related Parties, defined as each of a Defendant s past or present directors, officers, employees, partners, insurers, coinsurers, reinsurers, agents, controlling shareholders, attorneys, accountants, auditors, advisors, investment advisors, personal or legal representatives, predecessors, successors, parents, subsidiaries, divisions, joint ventures, assigns, spouses, heirs, related or affiliated entities, any entity in which a Defendant has a controlling interest, any members of an Individual Defendant s immediate family, or any trust of which an Individual Defendant is the settlor or which is for the benefit of an Individual Defendant s family. 2. Released Claims shall collectively mean all claims (including Unknown Claims as defined below), demands, rights, liabilities and causes of action of every nature and description whatsoever, known or unknown, whether or not concealed or hidden, asserted or that might have been asserted, including, without limitation, claims for negligence, gross negligence, breach of duty of care and/or breach of duty of loyalty, fraud, breach of fiduciary duty, or violations of any state or federal statutes, rules or regulations or common law principles, by the Lead Plaintiff or any Class Member against the Defendants or their Related Parties arising out of, relating to, or in connection with the purchase or the purchase and sale of the publicly-traded common stock of orthwest Biotherapeutics on the US and/or London markets by the Lead Plaintiff or any Class Member during the Class Period. 3. Unknown Claims shall collectively mean all claims, demands, rights, liabilities, and causes of action of every nature and description which the Lead Plaintiff or any Class Member does not know or suspect to exist in his, her or its favor at the time of the release of the Released Persons which, if known by him, her or it, might have affected his, her or its settlement with and release of the Released Persons, or might have affected his, her or its decision not to object to this settlement. The Lead Plaintiff and Class Members may hereafter discover facts in addition to or different from those which he, she or it now knows or believes to be true with respect to the subject matter of the Released Claims, but the Lead Plaintiff shall expressly fully, finally and forever settle and release, and each Class Member, upon the Effective Date, shall be deemed to have, and by operation of the Judgment shall have, fully, finally, and forever settled and released, any and all Released Claims, known or unknown, suspected or unsuspected, contingent or non-contingent, whether or not concealed or hidden, which now exist, or heretofore have existed, upon any theory of law or equity now existing or coming into existence in the future, including, but not limited to, conduct which is negligent, intentional, with or without malice, or a breach of any duty, law or rule, without regard to the subsequent discovery or existence of such different or additional facts. The Lead Plaintiff acknowledges, and the Class Members shall be deemed by operation of the Judgment to have acknowledged, that the foregoing waiver was separately bargained for and a key element of the settlement of which this release is a part. 4. This release shall be of no force or effect unless and until the Court approves the Stipulation and it becomes effective on the Effective Date. 5. I (We) hereby warrant and represent that I (we) have not assigned or transferred or purported to assign or transfer, voluntarily or involuntarily, any matter released pursuant to this release or any other part or portion thereof. 6. I (We) hereby warrant and represent that I (we) have included information about all of my (our) transactions in orthwest Biotherapeutics publicly-traded common stock on the US and/or London markets that occurred during the Class Period as well as the number and type of orthwest Biotherapeutics common stock held by me (us) at the opening of trading on April 17, 2007, and at the close of trading on October 15, 2007. *WBT1SIXTH* 6

First ame SUBSTITUTE FORM W-9 PART I. Request for Taxpayer Identification umber ( TI ) and Certification I. Last ame Check appropriate box: Individual/Sole Proprietor IRA Trust Corporation Partnership Pension Plan Other Enter TI on the appropriate line. (specify) For individuals, this is your Social Security umber ( SS ). However, for a resident alien, sole proprietor, or disregarded entity, see Part 1 of the enclosed W-9 instructions. For sole proprietors, you must show your individual name, but you may also enter your business or doing business as name. ou may enter either your SS or your Employer Identification umber ( EI ). For other entities, it is your EI. Social Security umber Employer Identification umber or PART II. For Payees Exempt from Backup Withholding If you are exempt from backup withholding, enter your correct TI in Part I and write exempt on the following line: PART III. Certification UDER THE PEALT OF PERJUR, I (WE) CERTIF THAT: (1) The number shown on this form is my correct TI; and (2) I (We) certify that I am (we are) OT subject to backup withholding under provisions of Section 3406(a)(1)(C) of the Internal Revenue Code because: (a) I am (we are) exempt from backup withholding; or (b) I (we) have not been notified by the Internal Revenue Service that I am (we are) subject to backup withholding as a result of a failure to report all interest or dividends; or (c) the Internal Revenue Service has notified me (us) that I am (we are) no longer subject to backup withholding. OTE: If you have been notified by the Internal Revenue Service that you are subject to backup withholding, you must cross out item 2 above. SEE ECLOSED FORM W-9 ISTRUCTIOS The Internal Revenue Service does not require your consent to any provision of this document other than the certification required to avoid backup withholding. I (We) declare under penalty of perjury under the laws of the United States of America that all of the foregoing information supplied on this Claim and Release form by the undersigned is true and correct. Executed this day of in (Month/ear) (City/State/Country) (Sign your name here) (Sign your name here) (Type or print your name here) (Type or print your name here) (Capacity of person(s) signing, e.g., Beneficial Purchaser, Executor or Administrator) (Capacity of person(s) signing, e.g., Beneficial Purchaser, Executor or Administrator) ACCURATE CLAIMS PROCESSIG TAKES A SIGIFICAT AMOUT OF TIME. THAK OU FOR OUR PATIECE. Reminder Checklist: 1. Please sign the above release and declaration. 2. Remember to attach supporting documentation, if available. 3. Do not send original stock certificates. 4. Keep a copy of your claim form and all supporting documentation for your records. *WBT1SEVETH* 7 5. If you desire an acknowledgment of receipt of your claim form please send it Certified Mail, Return Receipt Requested. 6. If you move, please send the Claims Administrator your new address.

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