EYEPOINT PHARMACEUTICALS, INC. GOVERNANCE AND NOMINATING COMMITTEE CHARTER

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1.0 Purpose EYEPOINT PHARMACEUTICALS, INC. GOVERNANCE AND NOMINATING COMMITTEE CHARTER The Governance and Nominating Committee (the Committee ) of the Board of Directors (the Board ) of EyePoint Pharmaceuticals, Inc. (the Company ) assists the Board in fulfilling its fiduciary responsibilities with respect to the oversight of the Company s affairs in the areas of corporate governance and Board membership matters. The purposes of the Committee shall be (a) to identify and recommend to the Board individuals qualified to serve as directors of the Company and to advise the Board with respect to the Board composition and procedures, (b) to oversee evaluation of the Board and the committees, and (c) to develop and maintain the Company s corporate governance policies, and (d) to ensure the Company s compliance with all applicable laws, regulations, internal rules and policies. 2.0 Membership The Committee shall comprise at least three (3) members of the Board, as determined from time to time by resolution of the Board, unless the Board otherwise determines, in its reasonable discretion, that the Committee shall comprise fewer than three (3) members. The Chair of the Committee (the Chair ) shall be designated by the Board. Each member of the Committee shall: (i) meet the independence requirements of the Nasdaq Stock Market LLC ( Nasdaq ) and its related rules and regulations, and (ii) be otherwise free from any relationship that, in the judgment of the Board, would interfere with his or her exercise of business judgment as a Committee member; and the Board shall annually review the Committee s compliance with such requirements. The members of the Committee will be appointed by and serve at the discretion of the Board based on recommendations from the Committee, which shall receive recommendations from the Chair of the Board. If a member of the Committee ceases to be a member of the Board, such individual s appointment to the Committee shall immediately be terminated. Any vacancy on the Committee shall be filled by the Board. No member of the Committee shall be removed except by the Board. The Board may remove any member from the Committee at any time, with or without cause. 3.0 Meetings and Procedures The Committee shall meet as often as it determines is necessary to carry out its responsibilities but, in no event, shall it hold fewer than four (4) meetings each year, either in person or telephonically. A majority of the members of the Committee present in person or by means of a conference telephone shall constitute a quorum. Formal action to be taken by the Committee shall be by unanimous written consent or by the affirmative vote of at least a majority of the members of the Committee present (in person or by telephone conference call) during a meeting at which a quorum is present, unless the concurrence of a greater proportion is required for such

action by the Company s bylaws or any other applicable policy or procedure approved by the Board. The Chair shall be responsible for calling the meetings, establishing the agenda and supervising the conduct thereof. The Committee shall maintain written minutes or other records of its meetings and activities. Minutes of each meeting of the Committee shall be distributed to each member of the Committee. The Secretary of the Company shall retain the original signed minutes for filing with the corporate records of the Company. The Chair shall report to the Board following meetings of the Committee and as otherwise requested by the Chair of the Board. 4.0 Responsibilities A. Board Candidates and Nominees The Committee shall have the following duties and responsibilities with respect to Board candidates and nominees: Identifying, recruiting and interviewing candidates for Board membership. Reviewing the background and qualifications of individuals being considered as director candidates. Among the qualifications considered in the selection of candidates, the Committee shall look at the following attributes and criteria of candidates: experience, skills, expertise, financial literacy, integrity, character, business judgment, time availability in light of other commitments, dedication, conflicts of interest and such other relevant factors that the Committee considers appropriate in the context of the needs of the Board, as well as factors relating to the composition of the Board, including its size, structure, diversity and the relative strengths and experience of current Board members. Developing and recommending to the Board guidelines and criteria to determine the qualifications, qualities, skills and other expertise of directors. Recommending to the Board the director nominees for election by the stockholders or appointment by the Board to fill any vacancies pursuant to the Bylaws of the Company, which recommendations shall be consistent with the criteria for selecting directors established by the Board from time to time, including compliance with the independence and other qualification requirements established by the Committee. Reviewing and considering director candidates recommended by the Company s stockholders pursuant to the procedures set forth in the Company s Stockholder Nomination Policy. 2

Reviewing the suitability for continued service as a director of each Board member when his or her term expires, and recommending whether or not the director should be re-nominated. B. Board and Committee Composition and Procedures The Committee shall have the following duties and responsibilities with respect to the composition and procedures of the Board as a whole: Monitoring the independence (within the meaning of the Nasdaq listing requirements) of Board members and the overall Board composition. Reviewing periodically with the Board the composition of the Board as a whole and recommending, if necessary, measures to be taken so that the Board reflects the appropriate balance of knowledge, experience, skills and expertise required for the Board as a whole and contains at least the minimum number of independent directors required by Nasdaq. Reviewing periodically the size of the Board and to recommend to the Board any appropriate changes. Making recommendations on the frequency and structure of Board meetings and on the practices of the Board. Making recommendations concerning any other aspect of the procedures of the Board that the Committee considers warranted, including but not limited to procedures with respect to the waiver by the Board of any Company rule, guideline, procedure or corporate governance principle. Recommending to the Board the directors to be appointed to each committee of the Board, including the Committee. Recommending to the Board the director to serve as chair of the Board. Recommending to the Board the director to serve as chair of each committee, including the Committee. Overseeing an orientation program for new Board members and continuing education for all Board members. C. Evaluation of the Board and Committees The Committee shall have the following duties and responsibilities with respect to evaluation of the Board and Committees: Overseeing an annual self-evaluation of the Board and its committees to determine whether the Board and its committees are functioning effectively. The Committee shall determine the nature of these evaluations, supervise the conduct of these 3

evaluations and prepare an assessment of the Board s and each committee s performance to be discussed with the entire Board. Evaluating annually the Committee s performance. Annually reviewing and assessing the adequacy of this Charter and recommending any proposed changes to the Board for approval. D. Corporate Governance Guidelines The Committee will develop and recommend to the Board a set of corporate governance guidelines applicable to the Company. From time to time as it deems appropriate, the Committee will review and reassess the adequacy of such corporate governance guidelines and recommend any changes to the Board for approval. The Committee shall perform the duties assigned to it in the corporate governance guidelines. E. Corporate Governance Practices; Disclosure of Corporate Governance Practices The Committee will review the Company s corporate governance practices, including identifying best practices, reviewing information regarding the operations of the Committee and the other Board committees, director independence, the director nominations process and the documents, policies and procedures in the Company s corporate governance framework on a periodic basis but at least annually. The Committee will discuss the results of its review with management, making recommendations relative to the nature of the corporate governance disclosure that should be included in the Company s proxy statement or annual report on Form 10-K, as applicable. F. Compliance Acknowledging that the Audit Committee of the Company shall have sole oversight over matters of financial compliance (including auditing, financial reporting, and disclosures to investors), the Committee shall have oversight responsibility for matters of non-financial compliance, including the Company s overall compliance programs, policies and procedures; significant legal or regulatory compliance exposure; and material reports or inquiries from government or regulatory agencies. G. Risk Management and Cybersecurity The Committee will oversee the Company s policies, if any, with respect to risk assessment and risk management. In the Committee s discretion, the Committee will periodically discuss the Company s plans or processes to monitor, control and minimize corporate risks and exposures (including with respect to information technology and cybersecurity) with the Company s external legal counsel, insurance advisors and the Company s independent registered public accounting firm. H. Other Duties 4

The Committee shall perform such other duties and responsibilities as may be assigned to the Committee from time to time by the Board. 5.0 Resources and Authority of the Committee The Committee shall have the resources and authority appropriate to discharge its responsibilities, including the authority to retain director search firms, consultants, outside legal counsel and other advisors as the Committee deems necessary to carry out its duties. The Company will provide for appropriate funding, as determined by the Committee, for payment of compensation to search firms, consultants, outside legal counsel and any other advisors retained by the Committee. Any communications between the Committee and legal counsel in the course of obtaining legal advice will be considered privileged communications of the Company and the Committee will take all necessary steps to preserve the privileged nature of those communications. 6.0 Subcommittees Subject to applicable law and Nasdaq rules, the Committee shall have the authority to delegate any of its responsibilities, along with the authority to take action in relation to such responsibilities, to one or more subcommittees as the Committee may deem appropriate in its sole discretion. Subject to applicable law and Nasdaq rules, the Chair may represent the entire Committee, as a subcommittee, with respect to functions of the Committee undertaken between meetings. Any actions of a subcommittee shall be presented to the full Committee at its next scheduled meeting. 7.0 Disclosure of Charter and Corporate Governance Principles This Charter and the Corporate Governance Principles shall be made available on the Company s website at http://www.eyepointpharma.com and to any stockholder who otherwise requests a copy. As amended and restated October 26, 2018 5