C-HEP SPONSORSHIP AND EXHIBITION PROSPECTUS CONTROVERSIES IN THE MANAGEMENT OF VIRAL HEPATITIS. 1 st World Congress on BARCELONA SPAIN MAY, 2011

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The Academy for Clinical Debates & Controversies in Medicine C-HEP 1 st World Congress on CONTROVERSIES IN THE MANAGEMENT OF VIRAL HEPATITIS BARCELONA SPAIN 19-22 MAY, 2011 SPONSORSHIP AND EXHIBITION PROSPECTUS Last update: December 12, 2010 www.comtecmed.com/chep chep@comtecmed.com

Dear Friends and Colleagues, T he field of Viral Hepatitis is experiencing vast expansion in clinical trials and basic research, as well as in emerging cutting-edge technology. Exciting new drugs are soon becoming available. The 1 st World Congress on Controversies in the Management of Viral Hepatitis (C-Hep) will function as a comprehensive forum where international experts share and debate state-ofthe-art management issues, such as appropriate use of new drugs, in order to outline the optimal treatment for patients. This innovative Congress is unique in its explicit focus on resolving controversies related to clinical management and treatment of patients infected with viral hepatitis. Controversies raised by recent advances in Hepatitis care will be addressed throughout the comprehensive meeting. Participants will have the advantage of discussing and debating these unresolved issues with leading world experts in all fields of Viral Hepatitis. Allowing ample time for speaker-audience discussion, the Congress aims at reaching up-to-date and agreed-upon answers to ongoing debates, even when data remains limited, through evidence-based medicine and expert opinion. We invite you to take part in the 1st C-Hep Congress which is intended as the inaugural event of annual future editions. We look forward to an exciting academic event in the beautiful city of Barcelona. Jürgen Rockstroh MD, Germany Jonathan M. Schapiro MD, Israel Co-Chairpersons 2

A. Alberti, Italy University of Padua CO-CHAIRPERSONS Jürgen Rockstroh MD, Germany Jonathan M. Schapiro MD, Israel B. Clotet, Spain HIV Unit and irsicaixa Foundation, University Hospital Germans Trias i Pujol, Badalona, Catalonia G. Dusheiko, UK UCL Centre for Hepatology, University College London Medical School, and Royal Free Hospital, London, UK G. Dore, Australia The National Centre in HIV Epidemiology and Clinical Research (NCHECR), University of New South Wales R. Esteban, Spain Vall d Hebron University Hospital S. Locarnini, Australia Victorian Infectious Diseases Reference Laboratory (VIDRL) SCIENTIFIC COMMITTEE P. Marcellin, France Hôpital Beaujon, Clichy S. Mauss, Germany Center for HIV and Hepatogastroenterology, Duesseldorf D.R. Nelson, USA University of Florida College of Medicine G. Papatheodoridis, Greece Athens University Medical School L. Peters, Denmark Copenhagen HIV Programme, University of Copenhagen M. Peters, USA Chief of Hepatology Research, Division of Gastroenterology, University of California, San Francisco V. Soriano, Spain Hospital Carlos III, Madrid M. Sulkowski, USA Johns Hopkins University School of Medicine H.L. Tillmann, USA Duke Clinical Research Institute H. Wedemeyer, Germany Hannover Medical School C. Yurdaydin, Turkey Ankara University Faculty of Medicine S. Zeuzem, Germany J.W. Goethe University Hospital, Frankfurt F. Zoulim, France INSERM Unit 871, Lyon University, and Hospices Civils de Lyon, Lyon, France 3

PRELIMINARY SCIENTIFIC PROGRAM THURSDAY, MAY 19, 2011 17:30-18:30 OPENING SESSION Welcome Remarks HONORARY OPENING LECTURE: Who has Hepatitis C in 2011? R. Esteban, Spain Hepatitis B: Any controversies left? G. Dore, Australia Discussion 18:30-20:00 WELCOME RECEPTION FRIDAY, MAY 20, 2011 HALL A HALL B HALL C 08:30-10:00 PLENARY SESSION 1 Chairpersons Welcome Address HCV Program Director: S. Zeuzem, Germany Direct Antivirals: The Future is Now Moderators: S. Zeuzem, Germany, R. Esteban, Spain Hcv Direct Acting Antivirals: What are they? C. Sarazin, Germany Who needs them? D. Nelson, USA How to use them? H. Wedemeyer, Germany Discussion 10:30-11:00 Coffee Break 10:30-12:00 PLENARY SESSION 2 First Line Therapy: Are there preferred options? Moderators: S. Zeuzem, Germany, R. Esteban, Spain HCV Protease inhibitors: are there preferences? PEG-IFN 2a vs. PEG-IFN 2b vs. New Interferons PEG-IFN 2a: S. Zeuzem, Germany PEG-IFN 2b: R. Esteban, Spain New Interferons: D. Dieterich, USA Discussion 12:00-13:15 JANSSEN CILAG SYMPOSIUM 13:15-14:00 Lunch Break 14:00-15:00 PLENARY SESSION 3 Liver Biopsies: End of the Game? New diagnostics for evaluating the liver: T. Poynard, France New diagnostics for evaluating the virus: J.M. Pawlotsky, France Discussion 15:00-16:00 SESSION 4 SESSION 5 SESSION 6 Is there still a need for liver Does drug resistance testing Frequent viral load monitoring: biopsies? have a clinical role in HCV Necessity or Luxury? therapy? Yes: Pro: C. Boucher, The Netherlands Necessity: V. Soriano, Spain No: T. Poynard, France Con: J.M. Pawlotsky, France Luxury: H. Tillmann, USA Discussion Discussion Discussion 16:00-16:30 Coffee Break 16:30-17:30 SESSION 7 Clinical Cases Treatment of Hepatitis C SESSION 7A SESSION 7B SESSION 7C Case 1: R. Bruno, Italy Case 2: L. Peters, Denmark Case 3: X. Forns, Spain 4

PRELIMINARY SCIENTIFIC PROGRAM SATURDAY, MAY 21, 2011 HALL A HALL B HALL C 09:00-10:00 SESSION 8 SESSION 9 SESSION 10 HIV/HCV Co-infected Incorporating genetic markers Acute Hepatitis C: what is new? Patients: Time to treat or time into routine clinical care: Moderator: J. Rockstroh, Germany to wait? Now or Later? Do we need ribavirin for Treat: S. Mauss, Germany Now: A. Rauch, Switzerland treatment of acute hepatitis C Wait: B. Gazzard, UK Later: U. Spengler, Germany in HIV coinfected patients? Discussion Discussion Yes: M. Nelson, UK No: M. Vogel, Germany Discussion 10:00-10:30 Coffee Break 10:30-12:00 PLENARY SESSION 11 HBV Therapy in 2011 HBV Program Director: F. Zoulim, France Moderators: F. Zoulim, France, M. Buti, Spain Hepatitis B Therapy: P. Lampertico, Italy Is Hepatitis B curable? F. Zoulim, France Interferon or oral anti-hbv drugs for first line therapy? Interferon: Oral anti-hbv drugs: M. Buti, Spain Discussion 12:00-13:15 MSD SYMPOSIUM 13:15-14:00 Lunch Break 14:00-15:30 PLENARY SESSION 12 Viral monitoring of HBV disease: Preventive and therapeutic vaccines for Viral Hepatitis (A & B): Treatment of Hepatitis Delta: H. Wedemeyer, Germany Treatment of Hepatitis B in pregnancy: C. Yurdaydin, Turkey Discussion 15:30-16:00 PLENARY SESSION 13 Hot topics in viral hepatitis 16:00-16:30 Coffee Break 16:30-17:30 PIPELINE SHOWCASE Moderator: J. Schapiro, Israel SUNDAY, MAY 22, 2011 09:00-10:30 PLENARY SESSION 14 Management of ESLD Treatment of HCC: What is new? M. Puoti, Italy Portal hypertension: state of the art. U. Spengler, Germany Liver Transplantation in 2011: M. Peters, USA Panel Discussion 10:00-10:30 Coffee Break 11:00-12:30 PLENARY SESSION 15 Beyond the horizon Can HCV be cured without interferon? Yes: H. Wedemeyer, Germany No: G. Duscheiko, UK Discussion The Future is Now J. McHutchison, USA 5

CONGRESS PROFILE AIMS OF THE CONGRESS To promote excellence in the field of Viral Hepatitis, by discussing, in a debate forum, evidencebased medicine and expert opinions on current controversial issues To bridge gaps between expansion of basic science and information, and their consolidation into clinical practice To promulgate ethics and standards of practice and treatment To reach consensus on certain controversial issues, through debates, round table discussions and plenary lectures To make it possible for the industry to meet with outstanding experts in the field, and to update international participants on pressing clinical and technological questions of the day C-HEP PROGRAM Educational Congress focused on clinical practices in Viral Hepatitis (especially in therapeutics) International Congress Only controversial topics World renowned speakers Cohesive and integrative sessions 40% Ample discussion time CME approved 6

CATEGORIES OF SPONSORSHIP Sponsorship levels which includes Satellite Symposia, Sponsorship Items and Exhibition PRESIDENTIAL CIRCLE 75,000 and up PLATINUM 50,000 75,000 GOLD 25,000 50,000 SILVER 10,000 25,000 SPONSOR 2,000 10,000 DEADLINE FOR CHOICE OF SPONSORSHIP OPTIONS Presidents Circle and Platinum September 1, 2010 Gold and Silver October 1, 2010 Exhibitors booking space with a contribution less than 5,000 will be acknowledged as "Exhibitors" 7

SCIENTIFIC SPONSORSHIP OPPORTUNITIES As outlined below, a number of opportunities for sponsorship are available. In addition to the individuale benefits of each package, all sponsors will be acknowledged on the official Congress website and in the final Congress program. CONTINUING MEDICAL EDUCATION (CME) 30,000 CMЕ (APPROVED SESSION) The Sponsor may provide an unrestricted grant to support an existing session or suggest a CME-approved session (1.5-2 hours) as part of the Scientific Program. The expenses of the chairpersons and speakers of the session (registration, accommodation and travel) will be the responsibility of the Sponsor. Session hall and standard audiovisual equipment Four complimentary registrations (for session chairpersons and speakers) A 100-word sponsor/product profile will be published in the final Congress Program Exhibition space of 12 sq.m (Additional space may be purchased at the reduced price of 400 per sq.m) Two complimentary registrations for exhibitors (Additional exhibitors registrations may be purchased at 350 per person) One A4 page advertisement, full color, will be included in the final Congress Program The Sponsor's logo will be published on the Congress Website, providing a two-way link The Sponsor's brochure will be inserted in the participants' bags SATELLITE SYMPOSIUM 40,000 (NON-CME APPROVED) The Sponsor may organize an industrial non-cme Satellite Symposium (1.5-2 hours) as part of the Scientific Program. Organizing Committee approval of the content and speakers is required. The date and time of the Symposium will be mutually agreed upon. The expenses of the chairpersons and speakers of the Symposium (registration, accommodation and travel) will be the responsibility of the Sponsor. Symposium hall and standard audiovisual equipment Five complimentary registrations (for Symposium chairpersons and speakers) A 100-word sponsor/product profile will be published in the final Congress Program Approximately 15 sq.m exhibition space (Additional space may be purchased at the reduced price of 400 per sq.m) Two complimentary registrations for exhibitors (Additional exhibitors registrations may be purchased at 350 per person) One A4 page advertisement, full color, will be published in the final Congress Program The Sponsor's logo will be published on the Congress Website, providing a two-way link The Sponsor's brochure will be inserted in the participants bags 8

SCIENTIFIC SPONSORSHIP OPPORTUNITIES PRE/POST-CONGRESS SATELLITE SYMPOSIUM 50,000 (NON-CME APPROVED) This option is particularly suited for drug launching and other special events The Sponsor may organize an industrial non-cme approved Pre/Post-Congress Satellite Symposium, for 3-4 hours (or more) on Thursday (May 19, 2011 ), before the official opening of the Congress, or at the end (May 23, 2011) of the Congress. The expenses of the chairpersons and speakers of the Symposium (registration, accommodation and travel) will be the responsibility of the Sponsor. Symposium hall and standard audiovisual equipment Six complimentary registrations (for Symposium chairpersons and speakers) A 100-word sponsor/product profile will be published in the final Congress Program Approximately 20 sq.m exhibition space (Additional space may be purchased at the reduced price of 400 per sq.m) Two complimentary registrations for exhibitors (Additional exhibitors registration may be purchased at 350 per person) One A4 page advertisement, full color, will be published in the final Congress Program The Sponsor's logo will be published on the Congress Website, providing a two-way link The Sponsor's brochure will be inserted in the participants bags EUROPEAN SPEAKER 3,000 The Sponsor may support in part the expenses of one or more invited European Speakers. Expenses include registration, accommodation and travel. A half-page advertisement, full color, will be published in the final Congress Program NON-EUROPEAN SPEAKER 6,000 The Sponsor may support in part the expenses of one or more invited Non-European Speakers. Expenses include registration, accommodation and travel. An A4 half-page advertisement, full color, will be published in the final Congress Program The Sponsor s brochure will be inserted in the participants' bags 9

SPONSORSHIP OPPORTUNITIES In addition to the scientific sponsorship opportunities, a range of other sponsorship packages is available to meet various needs. CONGRESS ABSTRACTS ON USB STICKS 10,000 The Scientific Abstracts of the Congress will be placed on USB sticks and distributed to all the participants of the Congress. Company logo on the USB stick Company profile in the Congress Program Book The Sponsor will be acknowledged in the final Congress Program, and the Sponsors logo will appear on a separate The Sponsors logo will appear on a Special Board on site CONGRESS PROGRAM 10,000 The final Congress Program will include the Scientific Program and the Scientific Abstracts of the Congress. The Congress Program will be distributed to all participants and will be an invaluable reference book after the Congress. One A4 page advertisement, full color, will be published on the back cover of the final Congress Program A 100-word sponsor/product profile will be published in the final Congress Program The Sponsor's logo will be published on the Congress Website providing a two-way link WELCOME RECEPTION 10,000 A Welcome Reception for all participants will be held on Thursday evening (May 19, 2011) at the Congress venue. The Sponsor s logo will appear on a special board at the Welcome Reception venue A 100-word sponsor/product profile will be published in the final Congress Program One A4 half-page advertisement, full color, will be published in the final Congress Program The Sponsor s brochure will be inserted in the participants' bags 10

SPONSORSHIP OPPORTUNITIES FACULTY DINNER 10,000 A Faculty Dinner will be held for the invited speakers of the Congress. The Sponsor s logo will appear on a special board at the Faculty Dinner venue INTERNET CENTER 10,000 The Internet Center will be outfitted with internet workstations for participants of the Congress to check their email and stay updated in-between sessions. The sponsorship package includes: workstations, areas for corporate logo display, technical support, furniture, adequate space for the workstations and internet set-up and connection. Display Sponsor logo/information on screensaver Display Sponsor logo/information on screen background Distribute mouse pads and related promotional gifts at the internet center The Sponsor will be acknowledged in the final Congress Program and the logo will appear on a separate Sponsor Logo page PARTICIPANTS BAGS provided-in-kind + 10,000 The Sponsor will provide the participants Congress bags. The Sponsor's brochure/s will be inserted in the participants' bags The Sponsor's logo will be published on the Congress Website, providing a two-way link The Sponsor s logo will appear on a Special Board on site 11

SPONSORSHIP OPPORTUNITIES MINI-POCKET PROGRAM 5,000 A Mini/Pocket Program will be distributed to all participants with their registration kits. The Sponsor s exclusive advertisement on the back cover of the Mini/Pocket Program The Sponsor's logo will be published on the Congress Website, providing a two-way link TRANSLATION (per hall, per day) 5,000 Simultaneous translation from English to any required language. The Sponsor s logo will appear on a special board in the session hall The Sponsor's logo will be published on the Congress Website, providing a two-way link WRITING PADS AND PENS provided-in-kind + 5,000 The Sponsor will provide all participants with writing pads and pens, which will be included in the participants bags. This can be an effective high-profile sponsorship opportunity for a drug launch or for immediate brand recognition. The writing pads and pens will bear the Sponsor s company product/logo CONGRESS LANYARDS The Sponsor provides printed lanyards for the name badges 3,000 The Congress provides printed lanyards for the name badges 6,000 This sponsorship opportunity is reserved for Platinum and Gold sponsors on a first-come, first-served basis The Sponsor/product name, logo or text printed on lanyards The Sponsor s logo will appear on a Special Board on site 12

SPONSORSHIP OPPORTUNITIES BROCHURE INSERT 3,000 A brochure provided by the Sponsor will be inserted into the participants bags, which will be distributed to the participants of the Congress. COFFEE BREAK (per coffee break) 2,000 Coffee will be served during the breaks between the sessions on each day of the Congress. All sponsorship and exhibition prices are subject to VAT. It is the Sponsors' and Exhibitors' responsibility to comply with the local authority's regulations, EFPIA (European Federation of Pharmaceuticals Industries & Associations) www.efpia.org and IFMPA (International Federation of Pharmaceutical Manufacturers & Associations) www.ifpma.org Code of Practice on the Promotion of Medicines. YOUNG SCIENTISTS 15,000 The sponsor may support up to 50 young scientists (age 36 and younger), with registration fees to the congress. The winners will be selected by the Scientific Committee after their extended abstract will be accepted. The winners will be notified with the name of the company that supported their participation. The sponsor's logo will be published in the congress web site. The sponsor will be acknowledged scientifically on a separate page in the final congress program. The sponsor will be acknowledged on the sponsor's board on site. The sponsor will receive the names and contact details of selected young scientists. 13

GENERAL INFORMATION VENUE Palau de Congressos de Catalunya Av. Diagonal, 661-671 Barcelona 08028, Spain Tel: +34 93 364 4400 Fax: +34 93 364 4401 Website: www.pcongresos.com LANGUAGE The official language of the Congress is English. CONGRESS SECRETARIAT AND SPONSORSHIP/ EXHIBITION CONTACT ComtecMed 53 Rothschild Boulevard, PO Box 68 Tel Aviv, 61000, Israel Tel: +972 3 5666166 Fax: +972 3 5666177 E-mail: chep@comtecmed.com Website: www.comtecmed.com/chep REGISTRATION FEES Registration fees include: Participation in scientific sessions, Congress bag, program and abstract book, all printed material of the Congress, invitation to the Welcome Reception, coffee breaks, lunch on Friday and Saturday. LIABILITY AND INSURANCE The Congress Secretariat cannot accept liability for personal accidents, nor for loss of, or damage to private property of participants, either during or directly arising from the 1 st World Congress on Controversies in the Management of Viral Hepatitis (C-Hep). Participants should make their own arrangements with respect to health and travel insurance. EXHIBITION A professional exhibition will be held at the Catlunia Convention Center, in conjunction with the Congress. The floor plan has been designed so as to maximize the exhibitors exposure to the delegates. Coffee breaks and lunches will be held in this exhibition area. EXHIBITION SPACE Sponsors may obtain additional exhibition space at 400 per sq.m. Non-sponsors may obtain exhibition space at 650 per sq.m. The minimum booth size is 6 sq.m Additional information about the exhibition will be available on the official website of the Congress. 14

EXHIBITION FLOORPLAN CATALUNIA CONVENTION CENTER REGISTRATION MAIN ENTRANCE ORGANIZER OFFICE SPEAKERS PREVIEW ROOM HALL A 3 1 3 6 2 2 4 5 6 7 2 2 8 9 3 3 3 HALL B 2 6 10 11 3 3 2 2 12 13 3 3 6 14 15 3 3 3 16 17 2 HALL C 15

C-HEP 1 st World Congress on CONTROVERSIES IN THE MANAGEMENT OF VIRAL HEPATITIS BARCELONA SPAIN 19-22 MAY, 2011 www.comtecmed.com/chep chep@comtecmed.com Headquarters and Administration: 53 Rothschild Boulevard, PO Box 68, Tel Aviv 61000, Israel Tel: +972-3-5666166 Fax: +972-3-5666177 Email: info@comtecmed.com Comtec Spain: Bailén, 95-97, pral. 1. a - 08009 Barcelona, Spain Tel: +34-93-2081145 Fax: +34-93-4579291 Email: spain@comtecmed.com Comtec China: 175 Xiang Yang Road South, Shanghai 200031 China Tel: +86-21-54660460 Fax: +86-21-54660450 Email: china@comtecmed.com