} Old IHR almost useless. } Increased need for international public health security and cooperation New diseases More international travel More people

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CEA Winslow The science and art of preventing disease, prolonging life, and promoting health through the organized efforts and informed choices of society, organizations, public and private communities, and individuals.

} Increased need for international public health security and cooperation New diseases More international travel More people } Old IHR almost useless Only cholera, plague and yellow fever Dependent on official notification No incentives for notifications No formal cooperation mechanisms No dynamics in international response

} Definitions and purpose } Surveillance and response } WHO recommendations concerning specific threats } Routine measures } Procedures } Reservations, disputes, etc

} A new international system for epidemic intelligence } A procedure for WHO s recommendations to guide the response to public health emergencies of international concern } A set of international rules on routine measures against international disease spread

The purpose and scope of these Regulations are to prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks, and which avoid unnecessary interference with international traffic and trade.

Decision instrument to determine whether an event may be a public health emergency of international concern (pheic)

High sensitivity, low positive predictive value Potential pheic notified by country Pheic declared by WHO

Communications Surveillance responsible Public health services Points of entry National IHR Focal Point WHO EURO IHR Focal Point Clinics and hospitals

Local level Capacities Surveillance } Detect outbreaks of disease or death } Report immediately to higher level Response } To implement preliminary control measures immediately

Regional level Capacities Surveillance Ø Confirm status of events Ø Assess events immediately Ø Report to national level Response Ø Support or implement additional control measures

National level Capacities Surveillance Ø Assess all events within 48 hours Ø Notify WHO Response Ø Determine control measures Ø Provide lab support Ø Provide on-site assistance Ø Provide operational links with officials, ministries, hospitals, entry points Ø Have emergency plan

Main challenges for countries 1. WHO s power to define an event 2. No political interference 3.Build capacities worldwide 4.No withholding of information 5.No excessive response

National laws on communicable diseases Stop the national spread of the disease Protect the rights of the individuals with disease and cause minimal harm

International law on communicable diseases (=IHR) Stop the international spread of the disease Protect the sovereignty of states and cause minimal harm (restrictions)

Autochthonous malaria cases - Greece 45 40 35 30 25 20 15 10 5 0 2009 2010 2011 2012 2013 2014 2015 2016 2017 Ø Almost every year sporadic autochthonous malaria cases in different regions in Greece Ø Greece is receptive to malaria

In collaboration with the Hellenic CDC and other involved parties, the following complementary actions against malaria were undertaken: Malaria surveillance: screening of 5516 asymptomatic immigrants for malaria during 2011-2016 Malaria treatment: chemoprophylaxis in 1309 immigrants, during 2013-2015 Increase of awareness amongst health professionals for the diagnosis of malaria Sensitization of the public and personal protection measures against mosquitoes Intensified vector control activities

Concluding remarks Ø The Evrotas program is the first antimalaria project applied in Europe after the end of the DDT era Ø The annihilation of autochthonous malaria cases in S. Peloponnese was the result of strong political and financial commitment Ø The protection of at risk populations was made possible with the combined actions of the health care system of Greece and the appropriate vector control applications Ø There was intense sensitization and community engagement Ø The ultimate goal was fulfilled: the protection of the people at risk, the prevention of the re-establishment of malaria in Greece and the protection of tourist industry.

} IHR is a major step forward in global epidemic intelligence Not perfect,for the moment in Greece but as good as was possible } Shifting power from countries to WHO (which works on behalf of all countries) Multilateral solutions } Actual use more important than when wording We can all make the IHR work by respecting the spirit of IHR: early sharing of information + the correct and non-excessive health measures } National capacity building is important