TB IN MIGRANT POPULATIONS Practical options chosen in neighbouring countries for screening and management

Transcription

1 25th Swiss Symposium on Tuberculosis Münchenwiler TB IN MIGRANT POPULATIONS Practical options chosen in neighbouring countries for screening and management SITUATION IN PARIS / FRANCE Fadi ANTOUN CENTRE DE LUTTE ANTITUBERCULEUSE, Bureau de la Prévention et des Dépistages, DASES 17 mars 2016

2 Many thanks to Delphine ANTOINE* for her help on epidemiological and demographic data and on the English version of this presentation. * InVS

3 TUBERCULOSIS IN FRANCE HISTORY

4 4

5 PARISIAN SLUMS EARLY TWENTIETH CENTURY 5

6 PARISIAN HEALTH VISITORS,

7 TUBERCULOSIS IN FRANCE EPIDEMIOLOGICAL DATA

8 INTERNATIONAL IMMIGRANTS, FRANCE POPULATION LIVING IN FRANCE 2014 FIGURES TOTAL POPULATION 65.8 millions IMMIGRANTS LIVING IN FRANCE 5.9 millions UNDOCUMENTED IMMIGRANTS POPULATION ENTERING IN FRANCE 2014 Figures IMMIGRANTS AUTHORISED TO STAY IN FRANCE AND SEEKING STAY PERMIT ASYLUM SEEKERS REFUGEES Source: INSEE, homme office

9 IMMIGRANT FLOW FROM 2005 TO 2015 (immigrants seeking a stay permit) X1000 Source : French Immigration Office

10 FRENCH IMMIGRATION OFFICE, STAYS PERMIT IN FRANCE Other 742 [6%] Humanitory [10%] Economic [9%] Students [31%] Familial [44%] 24% FROM AMERICA AND EUROPA - 8% < 20 YEARS Source : French Immigration Office

11 TUBERCULOSIS NOTIFICATION NUMBER AND RATE France, Number of cases (all forms) rate (all forms) per rate (TB pulmonary) per Number of cases Rate per , Year of notification Source : InVS, TB MANDATORY NOTIFICATION + INSEE (National Institute for Statistics and economy)

12 TUBERCULOSIS IN FRANCE, 2013 France : 65 millions inhabitants 4934 TB cases notified in 2013: rate = 7.5/ Born in France 44% Foreign born 56% Homeless persons 5.4% 2,2 million inhabitants 408 TB cases (8.3% of all cases) 18/ Ile de France region (Paris and suburb) 11 million inhabitants (including Paris) TB cases (36% of all cases) 14.7/ BEH, march 2015

13 TUBERCULOSIS NOTIFICATION RATE, Ile-de-France (IdF) (Paris Overseas and suburbs) Districts (DOM) France except IdF and DOM Paris TB rate per Year of notification Source : InVS, TB MANDATORY NOTIFICATION + INSEE (National Institute for Statistics and economy) Cellule Tuberculose / CLAT 75

14 TUBERCULOSIS NOTIFICATION RATE BY MAIN SOCIO-DEMOGRAPHIC CHARACTERISTICS, FRANCE, 2013 Taux pour ,6 176, 91,6 For each characteristic p<0,01 Source: InVS (Mandatory notification)

15 TUBERCULOSIS NOTIFICATION RATE BY PLACE OF BIRTH AND TIME SINCE ENTRY IN FRANCE, 2013 < 2 years 2-4 years 5-9 years 10 years and Rate per Total Foreign born Europe * Africa Asia Other regions Place of birth Europe: without France and including Central and East Europe Sources: InVS, mandatory notification and INSEE, population census

16 MDR * TUBERCULOSIS STRAINS RECEIVED AT THE NATIONAL REFERENCE CENTER(CNR-MYRMA), FRANCE, * TB MDR = TB Resistant to INH and RMP Source: CNR-MyrMA

17 TUBERCULOSIS CASES IN PARIS-2013 TB CASES HAVE DECREASED : 1200 CASES in 2003, 408 in 2013 and 324 in 2015 IN 2013 PARIS France without Paris TB incidence per % of TB cases in foreign born % of TB cases born in sub saharan Africa % of TB cases foreign born in shelter 72% 54% 29% 20% 6% NA % of TB cases in homeless 12% 4%

18 TB in migrants shelters N= 26 stable since 5 Y DISTRIBUTION OF CASES BY DISTRICT INCIDENCE BY DISTRICT IN 2013 XVII N= 408 TB in deprived and very deprived conditions N=120 XVIII XIX XVI VIII VII I IX II III IV X XI XX XV VI V XII Incidence XIV XIII < 10 / / / / North and East of Paris have highest incidence

19 MIGRANTS MIGRANT IMPACT ON TB IN PARIS, 2013 Parisian population 2,2 Millions MIGRANTS 72 % of TB cases including 6 % in shelter (n=26)

20 TB CONTROL

21 ORGANISATION OF TB CONTROL IN FRANCE, 2016 Clinicians TREATMENT+ FOLLOW UP Notification Notification Regional health agency (ARS-DT) Anti tuberculosis control center (CLAT) InVS EPIDEMIOLOGICAL ANALYSIS CONTACT INVESTIGATION ACTIVE X RAY SCREENING ARS-DT : District Unit of regional health authority CLAT : Anti tuberculosis control center InVS : National Institute for Public Health

22 TUBERCULOSIS CONTROL IN FRANCE 2005 : guidelines on TB and migrants 2007 : national TB programme and change of BCG policy from universal and mandatory vaccination to voluntary and at risk groups vaccination : National guidelines (High Council for public Health) 2013 : TB contact investigation 2014 : diagnostic and management of resistant TB Tuberculosis treatment IS FREE of charge for all REGIONAL HEALTH AUTORITHY (ARS) responsible for infectious disease control (of which TB) TUBERCULOSIS CENTER in charge of TB control at district level (CLAT)

23 NATIONAL REGULATIONS AND PRACTICE ON TB SCREENING IN MIGRANTS AS OF MARCH 2016 Type of immigrants Immigrants authorised to live in France for more than three months (except EEA residents) and seeking a stay permit Systematic medical visit : including TB Screening (Chest X Ray), vaccine, preventable diseases check ( diabetes, ) Performed in France except for immigrants seeking stay permit from Morocco, Mali, Tunisia, Turkey, Cameroon, Senegal (pre entry screening) No impact of the TB screening results on administrative process Asylum seekers Medical visit if in dedicated migrants shelter (only 20% of asylum seekers) Refugee Medical visit

24 RECENT FRENCH POLICY FOR IGRA USE AVIS DE LA HAS n /AC/SEAP du 3 juin 2015 Screening of LTBI for migrants < 15 years coming from high incidence countries including children < 5 years (2015) Quantitative presentation of results New French Pneumology Society Recommandations 2016 (not yet validated). IGRA OR TST. IGRA preferable to TST IF BCG OR RISK OF LOSS OF FOLLOW UP. INDIVIDUAL BUT NO SYSTEMATIC SCREENING OF MIGRANTS <35 YEARS COMING FROM HIGH INCIDENCE COUNTRIES

25 HIGH COUNCIL OF PUBLIC HEALTH REPORT 2005 French recommandations on tuberculosis and migrants Recommendations of expert group 'Tuberculosis and Migrants' Council senior public health of France, June 7, DGS

26 ALGORITHM LEGAL AND ILLEGAL MIGRANTS AND ASYLUM SEAKERS* < 15 YEARS > 15 YEARS TST CHEST X RAY TST > 10 mm TST < or = 10 mm TB DISEASE TB SEQUELAE NORMAL CHEST X RAY CHEST X RAY NO FOLLOW UP TREATMENT PREVENTIVE TREATMENT RECOMMENDATION : survey (chest X Ray/year) during 2 years** NORMAL ABNORMAL * if coming from high incidence countries>50/ PREVENTIVE TREATMENT TST > 10 mm without BCG TST > 15 mm with BCG or unknown BCG HEALTH ASSESSMENT AND TREATMENT ** if coming recently from very high incidence countries100/

27 OFII 2006 NATIONAL REGULATION ON MEDICAL SCREEENING OF IMMIGRANT SEEKING A STAY PERMIT Clinical Examination Chest X-RAY for all (except <10 years) TST only for those <15 years

28 CONTACT INVESTIGATION IN HOMELESS PERSONS AND MIGRANT SHELTERS French Guidelines PRECARIOUS (migrant/homeless shelter) with stay duration > 3-6 months GREAT PRECARIOUS (living in street or in a shelter <3 months) USUAL SCREENING (LTBI + TB screening for those in the same room) SPECIFIC SCREENING If 2 TB in 6 months period occuring in a shelter SCREENING TB for all shelter residents with chest X RAY using mobile Unit No screening for LTBI

29 SPECIAL MANAGEMENT OF TB MIGRANTS IN PARIS AND SUBURBS

30 35 avenue Courteline Paris o Regional mission (regional public health IDF Plan) implementation in 2010 Created in 1996 o Since its inception, ± 700 supported, including > 300 patients with TB treatment

31 More than 100 difficult TB (MDR + homeless) treated/year TB Center for inpatients with complex TB, acting as reference center for clinical advice for treatment and management of TB patients

32 TB SCREENING OF MIGRANTS AT ARRIVAL FRENCH IMMIGRATION OFFICE : 22 CENTERS DISPATCHED IN ALL FRENCH TERRITORY HEALTH CHECK AS PART OF PROCESS TO SEEK A STAY PERMIT RESULT OF HEALTH CHECK DO NOT IMPACT ON STAY PERMIT ISSUE UNDER THE AUTHORITY OF MINISTRY OF THE INTERIOR

33 LAST NATIONAL RESULTS, TB CASES /REGION N=194 TB / CHEST X-RAY = 98/ AFRIQUE ASIE EUROPE MAGHREB AMERIQUE Source : French Immigration Office

34 FRENCH IMMIGRATION OFFICE PROSPECTIVE STUDY 2014 COLLABORATION BETWEEN PARISIAN MIGRATION OFFICE AND CONTROL CENTER OF TB

35 PARISIAN PROSPECTIVE STUDY : from to MIGRANTS/YEAR ABOUT 1/8 OF ALL MIGRANTS TO FRANCE 96 ABNORMAL X-RAY MIGRANTS between and TB

36 PARISIAN PROSPECTIVE STUDY 2014 from to ABNORMAL CHEST X RAY N= 96 Region of birth (N=96) Sexe (N=96) Subsaharan North Africa South America South East Asia MEAN AGE (N=96) : 40,2 Years 8 East Europa Others (America/Canada/Mid dle East) DASES - lundi 6 mai 2013

37 PARISIAN PROSPECTIVE STUDY 2014 RESULTS (1) Delay Arrival in France (N=94) 104 months Consultation OFII mois mois mois > 36 mois Consultation OFII (N=95) 11 days Consultation CLAT Immediate answer Consultation OFII (N=95) 22 days Consultation CLAT Final answer DASES - lundi 6 mai 2013

38 PARISIAN PROSPECTIVE STUDY RESULTS (2) MIGRANTS AND 96 ABNORMAL X-RAY TB X-Ray SEQUELA 26 TB ACTIVE OTHER X-RAY SEQUELA 12 1 SMEAR + 11 SMEAR- 8 C + 49 OTHER DIAGNOSIS 1 mandibula cancer 100 TM/ X-RAY DASES - lundi 6 mai 2013

39 PARISIAN PROSPECTIVE STUDY CONCLUSIONS ACTIVE TB SCREENING among MIGRANTS NEWLY ARRIVED IS AN INTERESTING STRATEGY WITH A MEAN RATE OF 100 TB/ X-RAY THIS RATE IN BELOW WHAT WE EXPECTED BECAUSE OF : - LONG DELAY BETWEEN SCREENING AND ARRIVAL TIME - SCREENING OF ALL MIGRANTS INCLUDING THOSE COMING FROM LOW INCIDENCE COUNTRIES EFFICIENT COLLABORATION BETWEEN French Immigration Office And Anti-TB center IS NEEDED WITH REGULAR EVALUATION OF RESULTS MIGRANTS MUST BE SCREENED EARLIER AND ONLY THOSE COMING FROM HIGH INCIDENCE COUNTRIES (> 50/ 10 X 5)

40 Since 1994 mobile xray screening in Paris shelters TB ACTIVE SCREENING OF MIGRANTS IN PARIS SHELTERS - IN PARIS CITY 35 TO 40 MIGRANTS SHELTER WITH ALMOST 10 TO REGULAR RESIDENTS AND PROBABLY TWICE THIS NUMBER (if including indocumented residents) - LOOKING MORE AND MORE LIKE «ONE STAR HOTEL» - SYSTEMATIC SCREENING ONCE /Y AND MORE IF NECESSERLY

41 MOBILE X-RAY APPARITUS USED UNTIL 2013 TO SCREEN SHELTER POPULATION Cellule Tuberculose/CLAT

42 BPD Cellule Tuberculose/CLAT75 BPD Cellule Tuberculose/CLAT 75

43 MOBILE X-RAY SCREENING IN PARIS / NUMBER OF CHEST X RAY AND TB CASES SCREENED IN MIGRANTS SHELTER BETWEEN Number of Chest X Ray TB cases n Rx en foyers migrants n TM dépistées chez migrants In 2013 : CHEST X-RAY and 4 TB BPD Cellule Tuberculose/CLAT75 BPD Cellule Tuberculose/CLAT 75

44 CHEST X RAY SCREENING IN MIGRANT SHELTER 3 major periods in chest X Ray screening Chest X Ray in migrant shelter / Paris to 2001 : starting period efficiency 1 TM /600 XR (15% of all TB) 2002 to 2004 : epidemic period efficiency 1 TB/100 XR (40% of all TB) 2005 to 2011 : stabilisation period efficiency 1 TB/800 XR (10% of all TB ) JRVS 2013-FA BPD Cellule Tuberculose/CLAT75 Cellule Tuberculose / CLAT 75

45 TB CASES IN MIGRANT SHELTER, PARIS 2002 TO 2013 ALL TB CASES / TB CASES SCREENED BY MOBILE CHEST X RAY TB DRS TB Globales MOBILE X-RAY SCREENING IS EFFICIENT IN EPIDEMIC SITUATIONS WITH MORE THAN 50% OF ALL TB SCREENED BPD Cellule Tuberculose/CLAT75 BPD Cellule Tuberculose/CLAT 75

46 CONCLUSIONS IN PARIS BEFORE 2013 SYSTEMATIC ANNUAL SCREENING AFTER 2013 SCREENING in MIGRANT SHELTERS ONLY IF 2 TB occurs in 6 months period SYSTEMATIC ANNUAL SCREENING BY X-RY ALLOW 3 TB DIAGNOSIS (1 TB FOR 1000 XR)= 10 to 12% of all migrants shelter TB VERY EFFICIENT IN EPIDEMIC SITUATION WITH SEVERAL SIMULTANEOUS SCREENING IN HIGH RISK SHELTERS BPD BPD Cellule Cellule Tuberculose/CLAT75

47 ACTIVE SCREENING DIFFICULT COSTY ++ POOR RESULTS STRATEGIES CONTACT SCREENING STRATEGY (1% of CS = 1000 / CS ) SCREENING AT OFII (French immigration office ) about 100 TM / XR) SCREENING IN MIGRANT SHELTER = 100 TB / XR

48 ACTIVE SCREENING IN PARIS Index Cases In Contact Subject TB LTB I TB +TB prevented By treatment LTBI Contact screening French immigration Office Screening ( OFII) Active screening in migrant+homeless shelters TOTAL : 63 15% of all cases Cellule Tuberculose / CLAT 75

49 LTBI SCREENING OF MIGRANTS -FEW DATA in France concerning LTBI among migrant or general population -No Evaluation of LTBI in migrant < 15 Y despite a National Recommendation

50 DATA ON LTBI IN CHILDREN < 15 YEARS OLD-FRANCE In France, LTBI in children < 15 years should be notified (since 2003) whatever the situation Definition case : based for the moment on TST result Difficulty in assessing the exhaustivity of the surveillance system From 2011 to 2013: 2361 LTBI notified in children (around each year) Around 2/3 of LTBI in children foreign born or with foreign born parents

51 PARIS MIGRANTS < 15 YEARS YEAR NUMBER SCREENED LTBI TREATED ONLY LESS THAN 25 % OF MIGRANTS < 15 Y ARE SCREENED - AROUND 10 % WITH LTBI TREATED

52 CONCLUSIONS AND RECOMMENDATIONS BETTER SELECTION OF MIGRANTS : COUNTRY OF BIRTH WITH TB INCIDENCE > 50 / 10 X5 SCREENING SHOULD BE PERFORMED AS SOON AS POSSIBLE AFTER ARRIVAL IN FRANCE ASYLUM SEEKER SHOULD BE INCLUDED IN THE SCREENING LTBI SCREENING IN CHILDREN < 15 Y SHOULD BE ASSESSED AND EXPANDED IN A SECOND TIME LTBI SCREENING MAY BE PROPOSED FOR ALL MIGRANTS < 35 Y NEWLY ARRIVED FROM HIGH INCIDENCE COUNTRIES

53 LTBI SCREENING BY IGRA /Young adults from 16 to 30 Years If we consider sub-saharan migrants in France Number of persons concerned: about (1) Estimated number of QFT+ : à (20 à 25 %) (3) Number of TB avoided if LTBI treatment : 20 à 25 at 2 Years and 150 at 5 Years (2) 300 to 400 TB / To avoid 1 TB at 5 years : 133 migrants should be screened and 27 LTBI (IGRA+) should be treated (1 ) InVS mars 2009 (2) Mulder C, Van Deutekom H, et al. Role of the QuantiFERON -TB Gold In-Tube assay in screening new immigrants for tuberculosis infection. ERJ December 1, 2012;40(6): Gill AL, Ormerod LP, Watson JP. Positive predictive value of an interferon-gamma release assay for progression from latent to active tuberculosis in new-entrant screening. ERS 2014 (abstract) (3)-Pareek M, Bond M, and al. Community-based evaluation of immigrant tuberculosis screening using interferon gamma release assays and tuberculin skin testing : observational study and economic analysis. Thorax 2012:1-10 -Orlando G, Merli S, and al. Interferon-γ releasing assay versus tuberculin skin testing for latent tuberculosis infection in targeted screening programs for high risk immigrants. Infection 2010;38: Askekand Winje B, Oftung F, and al. Screnning for tuberculosis among newly arrived asylum seekers : comparison of QuanTIFERON TB Gold with tuberculin skin test. BMC Infectious Diseases 2008;8:65- -Ruff L, Hardman N, and al. Comparison of QuantiFERON -TB Gold positivity rates in an English city s targeted tuberculosis screening programme of new entrants with the WHO figures for tuberculosis incidence in their countries of origin. ESCMID 2013 (abstract